Changes in concentration of exhaled gas condensate medium during extracorporeal circulation in heart valve replacement surgery and its relationship with postoperative acute respiratory distress syndrome
Objective To analyzed the changes in exhaled breath condensate(EBC)concentration during cardiac valve replacement surgery under extracorporeal circulation and its relationship with postoperative acute respiratory distress syn-drome(ARDS).Methods Selected 78 patients undergoing heart valve replacement surgery in the First Affiliated Hos-pital of Henan University from January 2019 to December 2023.They were divided into an ARDS group of 41 patients and a non ARDS group of 37 patients based on whether they had ARDS.Compared the concentration changes of 8-iso-prostaglandinF2a(8-isoPGF2a),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),and inter-leukin-6(IL-6)between two groups of EBC,and their correlations with postoperative ARDS in patients undergoing heart valve replacement surgery were analyzed.Results After repeated measures analysis of variance,the time points,between-group,and interaction comparisons of 8-isopgF2a,TNF-α,IL-6,and IL-8 in EBC were statistically significant(P＜0.05);according to the LSD-t test,compared with the immediate time point after tracheal intubation(T1),the levels of 8-isopgF2a,TNF-α,IL-6,and IL-8 in EBC at the immediate time point after surgery(T2),2 hours post-surgery(T3),and 6 hours post-sur-gery(T4)were elevated in both groups(P＜0.05),and compared with the non-ARDS group,the levels of 8-isopgF2a,TNF-α,IL-6,and IL-8 in EBC at T2,T3,and T4 time points were higher in the ARDS group(P＜0.05).According to Spearman analysis,the levels of 8-isopgF2a,TNF-α,IL-6,and IL-8 in EBC at T2,T3,and T4 time points were positively correlated with postoperative ARDS after cardiac valve replacement surgery(P＜0.05).Conclusion In patients undergoing heart valve replacement surgery,the levels of 8-isopgF2a,TNF-α,IL-6,and IL-8 in EBC are elevated,and the levels of these markers in EBC are higher in postoperative patients with ARDS compared to those without ARDS.
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