首页|内镜下黏膜剥离术中采用Q法牵引技术治疗早期食管癌的疗效观察及近期预后观察

内镜下黏膜剥离术中采用Q法牵引技术治疗早期食管癌的疗效观察及近期预后观察

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目的 探究内镜下黏膜剥离术(endoscopic mucosald,ESD)中采用Q法牵引技术治疗早期食管癌的疗效及预后情况观察。方法 回顾性分析2020年4月—2022年12月间于濮阳市人民医院实施手术治疗的102例早期食管癌患者资料,根据手术方式的不同将患者分为ESD组和Q-ESD组,ESD组采用常规ESD治疗,Q-ESD组采用Q法牵引技术辅助ESD治疗,经倾向性评分配比法平衡两组基线特征差异所造成的混杂偏倚,最终获得30对基线资料可比的患者,比较两组手术相关指标、病灶切除效果、术后并发症情况,术后随访1年,比较两组复发及生存情况。结果 Q-ESD组剥离速度、剥离面积显著高于ESD组(P<0。05),手术时间、术中出血量、术中黏膜下补充注射量显著低于ESD组(P<0。05),两组住院时间比较,差异无统计学意义(P>0。05);Q-ESD组一次性整块切除率、治愈性切除率均显著高于ESD组(P<0。05),术后并发症总发生率显著低于ESD组(P<0。05);术后随访1年,两组均无死亡病例,术后6个月、1年内复发率比较,差异均无统计学意义(P>0。05),经K-M生存曲线分析,两组1年内无进展生存期比较,差异无统计学意义(P>0。05)。结论 Q法牵引技术辅助ESD治疗早期食管癌具有高效、安全、并发症少等优势,近期预后良好,值得临床推广。
Efficacy and short-term prognosis of Q-method traction technique during ESD in treating early esophageal cancer
Objective To investigate the efficacy and prognosis of Q-method traction technique during endoscopic sub-mucosal dissection(ESD)in the treatment of early esophageal cancer.Methods The data of 102 patients with early e-sophageal cancer who received surgical treatment in the hospital were retrospectively analyzed from April 2020 to Decem-ber 2022.According to the different surgical methods,the patients were divided into ESD group and Q-ESD group.The ESD group was treated with conventional ESD,whereas the Q-ESD group adopted Q-method traction technique-assisted ESD.The propensity score matching method was used to balance the confounding bias caused by the differences in baseline characteristics between the two groups.Finally,30 pairs of patients with comparable baseline data were ob-tained.The surgical related indicators,lesion resection effect and postoperative complications were compared.The pa-tients were followed up for 1 year,and the recurrence and survival status were compared.Results The peeling speed and peeling area in Q-ESD group were significantly higher than those in ESD group(P<0.05),and the surgical time,intraoperative blood loss and intraoperative submucosal injection volume were significantly shorter or lower than those in ESD group(P<0.05),but there was no statistical significance in hospital stay between the two groups(P>0.05).The one-time en bloc resection rate and curative resection rate in Q-ESD group were significantly higher(P<0.05),while the total incidence rate of postoperative complications was significantly lower than that in ESD group(P<0.05).At 1 year of follow-up after surgery,there were no deaths in the two groups,and there were no statistical differences in recurrence rates at 6 months and 1 year after surgery(P>0.05).According to K-M survival curve analysis,the progression-free survival time within 1 year showed no statistical difference between groups(P>0.05).Conclusion Q-method traction technique-assisted ESD has the advantages of high efficiency,safety and few complications in the treatment of early e-sophageal cancer,and it has good short-term prognosis.

Endoscopic mucosal dissectionQ-method tractionEsophageal cancerEfficacyPrognosis

董贾中、张峥峥、闫晓晖

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濮阳市人民医院消化内科一病区,河南濮阳 457000

内镜下黏膜剥离术 Q法牵引 食管癌 疗效 预后

2024

医药论坛杂志
中华预防医学会,河南省医学情报研究所

医药论坛杂志

影响因子:0.47
ISSN:1672-3422
年,卷(期):2024.45(24)