死亡结构域相关蛋白研究进展
Advances on death domain associated protein
王明月 1刘钰 1钱奕岑 1方婷婷 1刘胜兵1
作者信息
摘要
目的 死亡结构域相关蛋白(Death domain associated protein,DAXX)是分布在哺乳动物正常细胞和肿瘤细胞中的高度保守蛋白,其最初被鉴定为与Fas相关死亡结构域蛋白(Fas-associating protein with a novel death domain,FADD)结合参与凋亡调控,通过与早幼粒细胞白血病蛋白(Promyelocytic leukemia Protein,PML)结合参与细胞凋亡的调控.此外,DAXX也参与自噬、DNA损伤和细胞分化发育等多种功能.本研究就DAXX最近的研究进展作一综述.
Abstract
Death domain associated proteins(DAXX)are highly conserved proteins distributed in normal and tumor cells of mammals.They were initially identified as Fas death domain associated proteins involved in apoptosis regulation.Through their interaction with Promyelocytic leukemia Protein(PML),DAXX and PML binding proteins were involved in apoptosis.In addition,death domain related proteins are also involved in autophagy,DNA damage,cell differentiation and development.This paper reviews the latest research progress of DAXX.
关键词
死亡结构域相关蛋白/早幼粒细胞白血病蛋白/DNA损伤/自噬/分化Key words
DAXX/PML/DNA damage/Autophagy/Differentiation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据