Predictive value of systemic immune-inflammation index and albumin-fibrinogen ratio for bone metastasis in patients newly diagnosed with prostate cancer
Predictive value of systemic immune-inflammation index and albumin-fibrinogen ratio for bone metastasis in patients newly diagnosed with prostate cancer
Objective To investigate the predictive value of systemic immune-inflammation index(SII)and albu-min-fibrinogen ratio(AFR)for bone metastasis in patients with newly diagnosed prostate cancer.Methods Clinical data of 305 patients with prostate cancer was retrospectively reviewed,including 108 patients in the bone metastasis group and 197 patients in the no bone metastasis group.After adjusting for confounding factors,the effects of SII and AFR on bone metas-tasis rate of prostate cancer were analyzed by binary Logistic regression,the receiver operating characteristic curve was used to analyze the predictive power of SII and AFR for bone metastasis of prostate cancer.Results The SII of the bone metas-tasis group was 500.22(350.19～697.46)× 109/L,and the AFR was 11.53(9.91～12.87).The non bone metastasis group was 350.03(258.49～529.15)× 109/L and 13.84(11.69～15.95),respectively,with statistical significance(Z=10.335,P＜0.001;Z=12.101,P＜0.001).After adjusting for confounding factors,for every 1 standard deviation increase in SII,the odds ratio(OR)for bone metastasis was 1.001(1.000,1.002),and for every 1 standard deviation increase in AFR,the OR for bone metastasis was 0.812(0.717,0.919).The areas under the curves for SII and AFR in-dividual and combined detection are 0.671,0.717,and 0.747,respectively.The optimal cutoff value for detecting SII a-lone was 411.49 x 109/L,with a sensitivity of 68.52％and a specificity of 60.91％;The optimal cutoff value for detecting AFR alone was 13.35,with a sensitivity of 84.26％and a specificity of 55.84％.The sensitivity of SII+AFR combined detection was 72.22％,and the specificity was 70.05％.The area under the curve of SII+AFR combined detection was higher than that of SII alone detection(Z=2.396,95％CI:0.014-0.139,P＜0.001)and AFR(Z=2.062,95％CI:0.001-0.059,P＜0.001).Conclusion SII and AFR were associated with bone metastasis in patients with newly diag-nosed prostate cancer,and the efficiency of SII+AFR was higher than that of the single indicator.Therefore,the combina-tion of SII and AFR has better predictive value.
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