Treatment and survival prognosis analysis of peripheral T-cell lymphoma
Objective To analyze the clinicopathological features,survival outcomes and prognostic factors of pe-ripheral T-cell lymphoma(PTCL).Methods Clinicopathological features,survival outcomes and prognostic factors of PTCL were retrospectively analyzed in 253 patients.Survival analysis was performed by Kaplan-Meier method,and differ-ences between the study groups were compared by the log-rank test.The clinical and laboratory indicators were estimated with univariate and multivariate analyses by Cox proportional hazard model.Results The median age of the 253 patients was 60 years old,the 3-year,5-year and 10-year progression free survival(PFS)rates were 43.70％,36.60％and 20.60％,respectively,the 3-year,5-year and 10-year overall survival(OS)rates were 56.60％,49.20％and 30.00％,respectively.By multivariate Cox regression analysis,independent unfavorable prognostic factors for PFS was Ann Arbor stage(HR=3.600,95％CI=1.277-10.145,P=0.015),and independent unfavorable prognostic factors for OS were Ann Arbor stage(HR=4.812,95％CI=1.389-16.679,P=0.013)and international prognostic index score(HR=0.308,95％CI=0.109-0.870,P=0.026).In the GDPT regimen group,the overall response rate,the rates of PFS and OS were significantly higher than the CHOP regimen group(P=0.033,0.011,0.042).Conclusion Ann Arbor stage and IPI score were prognostic factors for PFS and OS.The GDPT is a promising new regimen and may become the first-line therapy for PTCL.
peripheral T-cell lymphomaprognostic factorinternational prognostic index score
万方数据
维普
