Clinical prognosis analysis of 106 patients with diffuse large B-cell lymphoma
Objective To investigate the clinical features and survival prognostic factors of diffuse large B-cell lym-phoma(DLBCL).Methods The clinical data of 106 patients with DLBCL admitted to the Department of Hematology of the First Affiliated Hospital of Zhengzhou University from April 2017 to May 2022 were retrospectively analyzed.The clini-cal characteristics and prognostic factors were analyzed.Results Among the 106 patients,64 patients were males and 42 patients were females.The median age was 62.5(19-87)years old,52.8％(56/106)were ≥ 60 years old,66.0％(70/106)had elevated lactate dehydrogenase(LDH),and 46.2％(49/106)had ≥2 exodular lesions.Bone marrow in-volvement accounted for 20.8％(22/106),Ⅲ-Ⅳ stage 67.0％(71/106),international prognostic index(IPI)score 0-1 point 26.4％(28/106),2 points 22.6％(24/106),3 points 16.0％(17/106),4-5 points 34.9％(37/106).Of 102 patients who received chemotherapy,90 patients completed the early efficacy evaluation,and the complete response rate was 52.2％(47/90).The analysis showed that patients with LDH＞240 u/L(x2=6.136,P=0.017)and IPI points of 3-5(x2=5.257,P=0.022)had low response rate.The median overall survival(OS)of the 106 patients was 533.5 days.Univariate analysis showed age(x2=7.061,P=0.008),B symptoms(x2=5.188,P=0.023),bone marrow involve-ment(x2=14.074,P＜0.001),stage(x2=4.03,P=0.049),LDH level(x2=5.219,P=0.022),β2-MG level(x2=10.979,P=0.001),IPI scores(x2=14.886,P=0.002),chemotherapy intensity(x2=36.992,P=0.001)were prognostic factors of DLBCL.Multivariate analysis showed that LDH level(HR=1.001,95％CI:1.0-1.001,P=0.004)and chemotherapy intensity(HR=0.403,95％CI:0.164-0.988,P=0.047)were independent factors affecting the prognosis of DLBCL patients.Conclusion The prognosis of DLBCL is the result of multiple factors,among which LDH level and chemotherapy intensity are independent factors affecting the prognosis.
diffuse large B-cell lymphomaclinical featuresprognosis
万方数据
维普
