Uterine inflammatory myofibroblastic tumor:a clinicopathological analysis of 3 cases and literature review
Objective To discuss the clinicopathological features,immunophenotypes,molecular genetics,differ-ential diagnosis and treatment of uterine inflammatory myofibroblastic tumor(IMT).Methods The clinicopathological fea-tures of 3 cases of uterine IMT in the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed,and re-viewed in combination with the related literature.Results The age of the three patients ranged 30 to 60 years.All tumors were intramural in location,with a medium or slightly soft texture and a mucus sensation.Histologically,two cases were mainly myxoid pattern,with myxoid stroma sparsely arranged in fascicles of spindle cells,similar to leiomyomas.Atypia of tumor cells were mild,with infiltration of inflammatory cell.The other case was associated with pregnancy.Histocytosis was a predominantly cellular type with features suggestive of invasive biology:invasive growth,frequent mitoses,and intravascu-lar growth.In addition,decidual-like neoplastic cells were seen focally.All the three tumors were ALK-positive with gran-ular cytoplasmic staining by immunohistochemistry.ALK gene rearrangements were detected by fluorescence in situ hybrid-ization in two tumors.No metastasis or recurrence was found during the postoperative follow-up.Conclusion The clinical and pathological features of uterine IMT overlap with smooth muscle tumors and endometrial stromal tumors.The diagnosis should be based on histological features and ALK immunohistochemistry,and genetic testing should be performed when nec-essary.
万方数据
维普
