首页|唾液酸结合免疫球蛋白样凝集素-15在食管鳞癌组织中的表达及意义

唾液酸结合免疫球蛋白样凝集素-15在食管鳞癌组织中的表达及意义

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目的 探讨免疫检查点唾液酸结合免疫球蛋白样凝集素-15(Siglec-15)在食管鳞癌中的表达及意义.方法 免疫组化检测食管鳞癌组织、癌旁正常食管组织中Siglec-15表达情况,并比较分析其与食管鳞癌患者临床病理特征的关系.结果 Siglec-15在食管鳞癌组织中表达阳性率为60.0％(48/80),高于癌旁正常食管组织中的23.75％(19/80)(x2=21.595,P＜0.001).食管鳞癌组织中Siglec-15蛋白表达与患者肿瘤直径、T分期、TNM分期、N 分期及分化程度有关(x2=7.500,P=0.006;x2=10.342,P=0.001;x2=22.547,P=0.016;x2=20.508,P＜0.001;x2=12.586,P=0.002).结论 Siglec-15在食管鳞癌组织中高表达,与患者的疾病进展显著相关.
Expression and significance of sialic acid-binding immunoglobulin-like lectin-15 in esophageal squamous cell carcinoma
Objective To investigate the expression and significance of immune checkpoint sialic acid-binding im-munoglobulin-like lectin-15(Siglec-15)in esophageal squamous cell carcinoma.Methods Immunohistochemical method was used to detect Siglec-15 expression in esophageal cancer tissue and adjacent tissue,and the relationship between Siglec-15 and clinicopathologic characteristics of esophageal squamous cell carcinoma.Results The Siglec-15 protein positive in esophageal squamous cell carcinoma tissues[60.0％(48/80)]was higher than that in normal esophageal tissues adjacent to the cancer[23.75％(19/80);x2=21.595,P＜0.001].There were statistical differences between Siglec-15 protein positivity and tumour diameter,T stage,TNM stage,N stage and degree of differentiation under different pathologies of esophageal squamous cell carcinoma(x2=7.500,P=0.006;x2=10.342,P=0.001;x2=22.547,P=0.016;x2=20.508,P＜0.001;x2=12.586,P=0.002).Conclusion Siglec-15 is highly expressed in esophageal squamous cell car-cinoma,and is related with disease progression.

immune checkpointsialic acid-binding immunoglobulin-like lectin-15esophageal squamous cell car-cinoma

郑晓东、张卫民

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安阳市肿瘤医院胸外科,河南安阳 455000

免疫检查点 唾液酸结合免疫球蛋白样凝集素-15 食管鳞癌

河南省医学科技攻关计划联合共建项目

LHGJ20191286

2024

10.3969/j.issn.1673-5412.2024.02.004

肿瘤基础与临床
河南省抗癌协会,郑州大学,河南省肿瘤医院,河南省肿瘤研究所

肿瘤基础与临床

影响因子：0.861
ISSN：1673-5412
年,卷(期)：2024.37(2)
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