Expression of human endogenous retrovirus-H long terminal repeat-associating 2 in human esophageal gastric junction adenocarcinoma
Objective To explore the expression of human endogenous retrovirus-H long terminal repeat-associating 2(HHLA2)in human esophageal gastric junction adenocarcinoma and its clinical significance.Methods The 126 pa-tients with esophageal gastric junction adenocarcinoma admitted to our hospital from March 2016 to Jue 2018 were randomly selected as the study subjects.Immunohistochemical staining was used to detect the expression of HHLA2 in the tumor tis-sue and corresponding adjacent tissues.The follow-up endpoint was patient death.A COX regression risk model was used for multivariate survival analysis,and the Kaplan Meier method was used to plot the survival curve.Results The positive expression rate of HHLA2 in patients with esophageal gastric junction adenocarcinoma was 68.9％(78/126),and the posi-tive expression rate of HHLA2 in adjacent tissues was 21.1％(27/126),with a significant statistical difference(x2=42.465,P＜0.001).Multivariate COX regression analysis showed that high expression of TNM stage and HHLA2 was asso-ciated with overall survival in patients with esophageal gastric junction adenocarcinoma(HR=4.217,P＜0.001;HR=2.467,P=0.003).The overall survival rate of patients with high expression of HHLA2 decreased compared to those with low expression(24.4％and 56.3％;x2=21.140,P＜0.001).Conclusion HHLA2 is highly expressed in gastric esophageal junction adenocarcinoma,which is significantly correlated with overall survival of patients.In addition,high ex-pression of HHLA2 and TNM stage is an independent risk factor for shortening overall survival of patients.
gastroesophageal junction adenocarcinomahuman endogenous retrovirus-H long terminal repeat-asso-ciating 2immunohistochemistry
NETL
NSTL
万方数据
