Objective To probe the effect of dexmedetomidine combined with remifentanil on stress response in pa-tients undergoing radical resection for esophageal cancer.Methods A total of 90 patients admitted to Zhoukou Central Hospital from March 2021 to March 2023 who underwent radical resection for esophageal cancer were arbitrarily grouped into the control group(n=45)and the observation groups(n=45).Patients in the control group were given intravenous anes-thesia with remifentanil,and patients in the observation group were given intravenous anesthesia with dexmedetomidine com-bined with remifentanil.The anesthesia-related indexes,immune function,stress response and toxicities were compared be-tween the two groups.Results Compared with the control group,the dose of remifentanil in the observation group was prominently lessened,and the awakening and the extubation time were prominently cut down(t=35.240,P＜0.001;t=11.810,P＜0.001;t=10.340,P＜0.001).Compared with the control group,the serum ACTH and COR levels in the observation group were dramatically lessened 3 days after operation(t=7.622,P＜0.001;t=4.467,P＜0.001).Com-pared with the control group,the adverse reaction rate in the observation group was prominently lessened(x2=4.406,P=0.036).Conclusion Dexmedetomidine combined with remifentanil could lessen the dose of anesthetic drugs in patients undergoing radical resection of esophageal cancer,reduce the stress response,have high safety,and have high clinical pro-motion value.
radical resection of esophageal carcinomaanesthesiadexmedetomidineremifentanilhemodynam-icsstress response
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