Construction of a risk prediction model for venous thrombosis after robot-assisted laparoscopic surgery for endometrial cancer
Objective To investigate the risk factors for venous thrombosis after robot-assisted laparoscopic surgery for endometrial cancer,and to construct a risk prediction model.Methods The clinical data of 133 patients who under-went robot-assisted laparoscopic endometrial cancer staging surgery in the First Affiliated Hospital of Zhengzhou University from January 2018 to September 2022 and were diagnosed with pathology after surgery were collected,and the risk factors for postoperative venous thrombosis in patients with endometrial cancer were analyzed by univariate and multivariate logistic regression analysis,and a risk prediction model was constructed.Results There were 35 cases of venous thrombosis after surgery(the thrombosis group)and 98 cases of no venous thrombosis(the non-thrombosis group),and the rate of postoper-ative venous thrombosis was 26.3%.Univariate analysis showed that age,comorbidities,pathological type,lymph node metastasis,International Federation of Gynecology and Obstetrics stage,D-dimer,C-reactive protein(CRP)and neutrophil-to-lymphocyte ratio(NLR)were statistically significant(t=15.847,P<0.001;t=11.107,P=0.004;t=18.015,P<0.001;t=7.668,P=0.006;t=9.381,P=0.025;t=8.764,P=0.003;t=4.879,P<0.001;t=3.094,P=0.004).Multivariate analysis showed that age,comorbidities,CRP and NLR were independent risk factors for venous thrombosis af-ter surgery(χ2=7.371,P=0.007;χ2=4.090,P=0.043;χ2=17.579,P<0.001;χ2=16.257,P<0.001).The postop-erative thrombosis prediction model was Logit(P)=-9.099+0.800X1+0.026X2+0.127X3+1.696X4,the area under the receiver operating characteristic curve was 0.887,sensitivity 74.3%,specificity 94.8%,model goodness-of-fit test suggested good predictive ability(χ2=10.336,P=0.242).Conclusion Age,comorbidities,CRP and NLR are inde-pendent risk factors for venous thrombosis after robot-assisted laparoscopic surgery for endometrial cancer.The risk predic-tion model constructed by this has a good degree of differentiation and calibration,which can effectively assess the risk of postoperative venous thrombosis,and corresponding prevention and treatment measures need to be given to such patients in clinical practice.
万方数据
维普
