Objective To investigate the expression level of claudin-11(CLDN11)in breast cancer and its prog-nostic value.Methods The mRNA levels of CLDN11 in breast cancer were analyzed using UALCAN and KM-Plotter data-bases.Secondly,its prognostic value was also analyzed.Finally,bc-GenExMiner V4.5 database was used to analyze the expression level of CLDN11 in breast cancer with different clinical parameters.Results CLDN11 mRNA levels were down-regulated in breast cancer compared to normal tissue(UALCAN database:P<0.001;KM-plotter database:P<0.001).Survival prognostic analysis showed that low expression of CLDN11 was associated with poorer overall survival[UALCAN database:P=0.037;KM-plotter database:HR=0.58(0.42～0.80),Log-rank P<0.001]and progression free survival[KM-plotter database:HR=0.66(0.57～0.77),Log-rank P<0.001]in breast cancer.CLDN11 mRNA level was correla-ted with different age(P<0.001),ER status(P<0.001),PR status(P<0.001),HER2 status(P<0.001),triple negative breast cancer(TNBC)subtype(P=0.001)and basal like TNBC subtype(P<0.001).Conclusion CLDN11 was down-regulated in breast cancer and can be used as a prognostic indicator.However,more experimental studies are needed to confirm the molecular mechanism.
关键词
乳腺癌/紧密连接蛋白-11/生物信息学/无进展生存期/总生存期/预后指标
Key words
breast cancer/claudin-11/bioinformatics/progression free survival/overall survival/prognostic marker
维普
万方数据