Clinical value of combined detection of serum tissue polypeptide-specific antigen,neutrophil-to-lymphocyte ratio and albumin-globulin ratio in prognostic assessment of papillary renal cell carcinoma
Objective To evaluate the efficacy of combined detection of serum tissue polypeptide-specific antigen(TPS),neutrophil-to-lymphocyte ratio(NLR)and albumin-globulin ratio(AGR)in predicting the prognosis of papillary renal cell carcinoma.Methods We retrospectively analyzed 130 patients with papillary renal cell carcinoma who were trea-ted and followed up for 18 months from February 2021 to October 2022 at our hospital,serving as the observation group,and also selected 130 healthy individuals from the same period as the control group.The levels of serum TPS,NLR,and AGR were compared between the two groups,and the changes in these indicators under different survival states of the obser-vation group were analyzed.Results The serum levels of TPS and NLR in the observation group were higher than those in the control group,while the AGR was lower than that in the control group(t=17.929,P<0.001;t=13.431,P<0.001;t=15.773,P<0.001).The serum levels of TPS and NLR of the deceased patients were higher than those of surviving pa-tients,while the AGR was lower than that in the control group(t=5.310,P<0.001;t=7.090,P<0.001;t=3.845,P<0.001).The high TPS and NLR,and low AGR were the independent influencing factors for the patients.The prognostic ef-ficacy analysis showed that the area under the curve for TPS,NLR and AGR,as well as their combined prediction of papil-lary renal cell carcinoma patient prognosis,were 0.715,0.832,0.682 and 0.941,respectively.Conclusion The com-bined detection of TPS,NLR,and AGR has high prognostic efficacy for patients with papillary renal cell carcinoma,and high levels of TPS and NLR,along with low AGR,are unfavorable factors for patient prognosis.
万方数据
维普
