Efficacy and safety analysis of anlotinib combined with icotinib hydrochloride in the first treatment of epidermal growth factor receptor mutation positive non squamous non small cell lung cancer patients with brain metastasis
Objective To investigate the efficacy and safety of anlotinib combined with icotinib in the first treatment of epidermal growth factor receptor(EGFR)mutation positive non-squamous non-small cell lung cancer with brain metasta-sis.Methods From June 2018 to November 2021,61 patients with EGFR mutation positive non-squamous non-small cell lung cancer complicated with brain metastasis in the Puyang Oilfield General Hospital were collected and randomly divided into two groups,and 29 patients in the observation group were treated with anlotinib combined with icotinib,32 patients in the control group were treated with icotinib alone.The efficiency,survival and adverse reactions were compared between the two groups.Results The objective response rate and disease control rate in the observation group were higher than those in the control group(χ2=10.314,P=0.001;χ2=5.710,P=0.017).The objective response rate and disease control rate of intracranial lesions in the observation group were higher than those in the control group(χ2=4.697,P=0.030;χ2=4.638,P=0.031).The median progression-free survival time of patients in the observation group was10.3 months(95%CI:9.25-11.35 months),while that of patients in the control group was 7.4 months(95%CI:5.55-9.26 months;P=0.004).The incidence of hemoptysis,oral mucositis pain and hypertension in the observation group was higher than that in the control group(χ2=7.015,P=0.008;χ2=11.663,P=0.001;χ2=14.962,P<0.001).No treatment interruption or treatment-related deaths occurred in the two groups.Conclusion Anlotinib combined with icotinib as the first-line treat-ment for patients with EGFR mutation positive non-squamous non-small cell lung cancer complicated with brain metastasis can control the disease progression,prolong the progression-free survival,and is relatively safe.
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