Predictive value of serum potassium,red blood cell count and hemoglobin for disease progression-free survival of prostate cancer after endocrine therapy
Objective To investigate the predictive value of serum potassium,red blood cell count and hemoglobin before treatment for progression-free survival(PFS)of prostate cancer patients after endocrine therapy.Methods The clinical data of 190 patients with prostate cancer admitted to the First Affiliated Hospital of Zhengzhou University from Janu-ary 2013 to December 2017 were collected.The factors that may affect the prognosis of prostate cancer were extracted,in-cluding age of patients,TNM stage of prostate cancer,Gleason score of prostate cancer,type of endocrine therapy drugs.And the six hematological indicators before treatment were extracted,including fasting serum potassium concentration,red blood cell count,hemoglobin concentration,alkaline phosphatase concentration(ALP),white blood cell count and platelets count.Results The median PFS of 190 patients was 40.8 months.Kaplan-Meier survival analysis showed that TNM stage(P=0.046),fasting serum potassium concentration(P=0.014),red blood cell count(P=0.029),hemoglobin concen-tration(P=0.018)and ALP(P=0.008)were associated with PFS in the prostate cancer patients.There was a signifi-cant positive correlation between hemoglobin concentration and red blood cell count(r=0.869,P<0.001).TNM stage,fasting serum potassium concentration,red blood cell count and ALP were included in COX proportional risk regression model for multivariate survival analysis.The results showed that TNM stage(P=0.007),fasting serum potassium concen-tration(P=0.006)and red blood cell count(P=0.018)were independent prognostic factors for predicting PFS.Conclu-sion TNM staging,fasting serum potassium concentration and red blood cell count before treatment are the independent prognostic factors for PFS of prostate cancer patients after endocrine therapy.Prostate cancer patients with earlier TNM stage,lower fasting serum potassium concentration in the normal range or normal red blood cell count had longer PFS than patients with later TNM stage,higher fasting serum potassium concentration in the normal range or lower red blood cell count.
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