Prognostic value of preoperative prognostic nutritional index-D-Dimer score in the colorectal cancer
Objective To explore the prognostic value of preoperative prognostic nutritional index(PNI)-D-Dimer(D-D)score(PDS)in the colorectal cancer.Methods A retrospective study was conducted on patients with colorectal cancer who underwent radical surgery and were admitted to Xihua County People's Hospital from January 2019 to December 2022.According to the levels of PNI and D-D,the patients were divided into the PDS0 group(PNI decreased and D-D in-creased),the PDS1 group(PNI decreased and D-D decreased or PNI increased and D-D increased),and the PDS2 group(PNI increased and D-D decreased).disease-free survival and overall survival between the two groups were compared by u-sing Kaplan-Meier method and Log-rank test,and the risk factors for prognosis was determined.Results The 67 patients with colorectal cancer were included in this study,including 21 patients with PDS0,24 patients with PDS1,and 22 patients with PDS2.PNI,D-D and PDS all had predictive value for disease progression-free survival and overall survival in patients with colorectal cancer,with areas under the curve of 0.776(0.715-0.838),0.729(0.669-0.790),0.795(0.736-0.853)and 0.789(0.723-0.855),0.739(0.676-0.803),0.817(0.757-0.877),respectively.PDS had the largest area under the curve and the best performance in predicting disease progression-free survival and overall survival.There were significant differences in disease progression-free survival and overall survival between PDS subgroups(P<0.001).Multivariate COX proportional hazards regression analysis showed that PNI,D-D and PDS were closely related to disease progression-free survival and overall survival(P<0.001).Conclusion PDS is a useful prognostic indicator for patients with colorectal cancer after radical surgery,and the survival of patients with PDS0 is poor.
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