Efficacy of stereotactic surgery for patients with brain glioma and its impact on ser-um levels of ubiquitin conjugating enzyme 2C and CXC chemokine ligand 10
Objective To analyze the efficacy of stereotactic surgery for patients with brain glioma and its impact on ser-um levels of ubiquitin conjugating enzyme 2C(UBE2C)and CXC chemokine ligand 10(CXCL10).Methods The clinical data of 45 patients with glioma in the Third Affiliated Hospital of Xinxiang Medical University from January 2018 to February 2023 were collected,they were divided into two groups according to different surgical methods:22 cases of the control group re-ceived traditional craniotomy treatment,and 23 cases of the observation group received stereotactic surgery treatment.The effi-cacy and 1-year survival rate were compared between the two groups,as well as the levels of neurological function[neurological impairment severity scale(NIHSS)],immune cells[T helper cell(Th)1,Th2,Th17],life ability[Barthel index(BI)],serum ubiquitin-conjugating enzyme 2C(UBE2C),CXC chemokine ligand 10(CXCL10)and inflammatory cell factors[tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),IL-2,IL-6]levels before and 6-month after operation.Results The to-tal effective rate of the observation group(100.00%)was higher than that of the control group(72.73%;χ2=5.070,P=0.024);the 1-year survival rate of the observation group(86.96%)was higher than that of the control group(54.55%;χ2=5.750,P=0.017).Six months after surgery,the NIHSS score of the observation group was lower than that of the control group,and the BI score was higher than that of the control group(t=6.728,P<0.001;t=5.339,P<0.001).Six months after surgery,the Th1 level in the observation group was higher than that in the control group,while the Th2 and Th17 levels were lower than those in the control group(t=3.793,P<0.001;t=4.691,P<0.001;t=5.293,P<0.001).Six months after surgery,the serum levels of UBE2C,CXCL10,TNF-α,IL-17,IL-2 and IL-6 in the observation group were lower than those in the control group(t=8.778,P<0.001;t=3.543,P=0.001;t=9.831,P<0.001;t=11.148,P<0.001;t=11.516,P<0.001;t=10.954,P<0.001).Conclusion Stereotactic surgery for the treatment of brain glioma has significant effects,which can effectively improve patients'neurological function,immune function and living ability,inhibit the expression of ser-um inflammatory cytokines,UBE2C and CXCL10,and improve survival.
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