Objective:To explore the anti-inflammatory,antipyretic and analgesic pharmacological effects of Xiaoer Fengreqing mixture.Methods:The mouse ear swelling model induced by xylene was used,and the contents of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β)and interleukin-10(IL-10)in serum of mice were determined to evaluate the anti-inflammatory pharmacological effect of Xiaoer Fengreqing mixture.Rat fever model induced by dry yeast was used to evaluate the antipyretic pharmacological action of Xiaoer Fengreqing mixture.Acetic acid induced pain twisting method and hot plate test were used to evaluate the analgesic pharmacological action of Xiaoer Fengreqing mixture.Results:The positive control group and Xiaoer Fengreqing low,medium and high dose groups showed lower degree of ear swelling induced by xylene than model group,and the differences were statistically significant(P＜0.01 or P＜0.05);Xiaoer Fengreqing medium and high dose groups showed lower serum TNF-α content than model group,and the differences were statistically significant(P＜0.01);Xiaoer Fengreqing high dose group showed lower serum IL-6 content than model group(P＜0.05).Xiaoer Fengreqing high dose group showed lower spleen index than model group(P＜0.05).Xiaoer Fengre-qing low dose,medium dose and high dose groups showed lower body temperature than model group,and there was a dose-dependent relationship,with statistical significance(P＜0.01 or P＜0.05).Xiaoer Fengreqing medium and high dose groups showed less writhing reaction times than model group(P＜0.05).Xiaoer Fengreqing mixture could improve the pain threshold of hot-plate experiment in mice.With the increase of Xiaoer Fengreqing mixture dose,the pain threshold of mice showed a positive correlation,and the difference was statistically significant(P＜0.05).The analgesic effect reached the peak within 60 minutes.Conclusion:Xiaoer Fengreqing mixture has good anti-inflammatory and antipyretic pharmacological effects.
维普
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