Clinical Observation on the Treatment of Infertility Related to Decreased Ovarian Reserve Function with Bushen Jianpi Formula(补肾健脾方)
Objective:To study the clinical efficacy of Bushen Jianpi Formula in treating infertility related to ovarian reserve dysfunction with spleen and kidney deficiency syndrome.Methods:60 patients with ovarian reserve dysfunction of spleen and kidney deficiency were randomly divided into treatment group and control group,30 cases in each.The treatment group was given Bushen Jianpi Formula,and the control group was given femoston.Both groups of patients were treated continuously for 6 cycles.Sexual hormone indicators[follicle-stimulating hormone(bFSH),luteinizing hormone(bLH),serum estradiol(E2),anti-Mullerian hormone(AMH)],ultrasound indicators[ovarian volume,number of sinus follicles(AFC)]were detected.The TCM syndrome score,total effective rate,pregnancy rate,abortion rate of the two groups were compared,and the safety indicators were monitored.Results:The total effective rate of the treatment group was 79.31％(23/29),while the total effective rate of the control group was 82.14％(23/28),with no statistically significant difference(P＞0.05).After 6 menstrual cycles of treatment,the traditional Chinese medicine syndrome score and bFSH in both groups decreased compared to before treatment(P＜0.05),while AMH increased compared to before treatment(P＜0.05),and the treatment group was better than the control group(P＜0.05).After treatment,bLH in the treatment group decreased compared to before treatment(P＜0.05);There was no statistically significant difference in bLH between the control group before and after treatment(P＞0.05).After treatment,there was a significant increase in E2 levels between the two groups compared to before treatment(P＜0.05).There was no statistically significant difference in E2 levels between the two groups of patients after treatment(P＞0.05).After treatment,the ovarian volume in the treatment group significantly increased(P＜0.05),and the number of sinus eggs significantly increased(P＜0.05).The treatment group was significantly better than the control group(P＜0.05).The pregnancy rate in the treatment group[34.48％(10/29)]was higher than that in the control group[21.43％(6/28)](P＜0.05),and the abortion rate in the treatment group[10.00％(l/10)]was lower than that in the control group[33.30％(2/6)](P＜0.05).No abnormalities were found in the safety indicators of the two groups of patients before and after treatment,and no adverse reactions occurred.Conclusion:The Bushen Jianpi Formula can safely and effectively treat infertility with decreased ovarian reserve function with spleen and kidney deficiency syndrome,improve ovarian related hormone levels,increase pregnancy rate,reduce miscarriage rate,and alleviate clinical symptoms.
infertilitydecreased ovarian reserve functionspleen and kidney deficiency syndromeBushen Jianpi FormulaIceberg theory
万方数据
维普
