Analysis of the"Warm Yang and Accumulation Method"in the Treatment of Membranous Nephropathy Based on Data Mining
Objective:To analyze the medication rule in the treatment of membranous nephropathy with"warm Yang and accumulation method"based on data mining.Methods:A total of 420 patients with membranous nephropathy treated in the outpatient department of Dongzhimen Hospital,Beijing University of Chinese Medicine from January 2021 to August 2022 were selected as the research subjects.Statistical analysis was conducted on the initial prescriptions of all patients.SPSS Modeler 18.0 software was used for drug frequency analysis,entropy level clustering method was used to analyze the formula composition rules,and Aprior algorithm was used for drug association rule analysis.Using cluster analysis method with inter group connections to analyze core drug combinations in prescriptions.Results:A total of 659 initial diagnosis prescriptions were collected,with a total of 129 drugs collected.38 high-frequency drugs with a usage frequency of≥2％were used.Among them,traditional Chinese medicines ingredients with a usage frequency of over 90％were Fuzi(Aconiti Radix Lateralis Praeparata),Fuling(Poria),Mahuang(Ephedrae Herba),and Zhigancao(Glycyrrhizae Radix cum Liquido Fricta).The traditional Chinese medicines ingredients with a usage frequency of 60％to 89％were Fuchaobaizhu(Atractylodis Macrocephalae Rhizoma Stir-fried with Bran),Ganjiang(Zingiberis Rhizoma),Dazao(Jujubae Fructus),Guizhi(Cinnamomi Ramulus),Fangji(Stephaniae Tetrandrae Radix),Chixiaodou(Phaseoli Semen),Huangqi(Astragali Radix),Zexie(Alismatis Rhizoma),and Huluba(Trigonellae Semen).It mainly consists of warm internal medicine,surface relieving medicine,tonifying deficiency medicine,diuretic and dampness absorb ing medicine,etc.The ingredients of traditional Chinese medicine combinations with a frequency of over 50％were Mahuang(Ephedrae Herba)and Fuzi(Aconiti Radix Lateralis Praeparata),Fuzi(Aconiti Radix Lateralis Praeparata)and Ganjiang(Zingiberis Rhizoma),Fangji(Stephaniae Tetrandrae Radix)and Huangqi(Astragali Radix)and Fangji(Stephaniae Tetrandrae Radix),Fuling(Poria)and Fuzi(Aconiti Radix Lateralis Praeparata),Fangji(Stephaniae Tetrandrae Radix),and etc.In the analysis of drug combination association rules,the top three confidence levels were:Mahuang(Ephedrae Herba),Fuzi(Aconiti Radix Lateralis Praeparata)-Fangji(Stephaniae Tetrandrae Radix);Fuzi(Aconiti Radix Lateralis Praeparata),Fuling(Poria)-Huangqi(Astragali Radix);Huangqi(Astragali Radix),Mahuang(Ephedrae Herba)-Fangji(Stephaniae Tetrandrae Radix).The results of core drug combinations were analyzed by cluster analysis method of inter-group linkage,and a total of 12 categories were obtained.Four clustering formulas were obtained from high-frequency drug clustering.Conclusion:According to the medication patterns of LIU Baoli in the treatment of membranous nephropathy through data mining,combined with methods such as relieving external symptoms,tonifying deficiency,and promoting diuresis and dampness on the basis of warm Yang and accumulation method,it has certain reference significance for the clinical treatment of membranous nephropathy.
membranous nephropathywarm Yang and accumulation methodmedication patternsdata miningLIU Baoli
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