The Medication Rule of Ancient and Modern for Vitiligo Based on Association Rules and Latent Structure Model
Objective:To explore and analyze the medication rules and compatibility characteristics of ancient and modern prescriptions for clinical treatment of vitiligo.Methods:Clinical research literature about vitiligo was retrieved from ancient books and CNKI,Wanfang,and VIP from January 1,2013 to January 1,2023.And database was established.Frequency analysis,association rule analysis,latent structure model analysis,cluster analysis,and factor analysis on traditional Chinese medicine were carried out through software.Results:A total of 129 prescriptions and 286 traditional Chinese medicines were selected,with a total use frequency of 1316.In ancient prescriptions,the herbs with high usage frequency included Fangfeng(Saposhnikovia divaricate),Fuzi(Monkshood)and Kushen(Sophora flavescens)etc.And relieving exterior syndrome drugs,deficiency-nourishing d rugs and wind damp dispelling drugs were mainly used.In terms of nature,warm,plain and cold ranked among the top three.In terms of flavor,the proportion of spicy,bitter and sweet was the highest.In terms of meridian distribution,liver,spleen and lung were the most critical.A total of 19 groups of potential drug combinations of high-frequency Chinese medicine were excavated.Latent structure model analysis yields six latern variables,to infer three core prescriptions according to traditional Chinese medicine knowledge.A total of five clustering combinations can be formed based on clustering analysis of high frequency drugs.A total of 8 common factors were extracted.In modern prescriptions,the herbs with high usage frequency included Danggui(Angelica sinensis),Buguzhi(Fructus psoraleae)and Cijili(Tribulus terrestris)etc.And relieving deficiency-nourishing drugs,blood activating and stasis removing drugs and relieving exterior syndrome drugs were mainly used.In terms of nature,warm,plain and cold ranked among the top three.In terms of flavor,the proportion of sweet,spicy and bitter was the highest.In terms of meridian distribution,liver,spleen and lung were the most critical.A total of 22 groups of potential drug combinations of high-frequency Chinese medicine were excavated.Latent structure model analysis yields 10 latern variables,to infer five core prescriptions according to traditional Chinese medicine knowledge.A total of five clustering combinations can be formed based on clustering analysis of high frequency drugs.A total of nine common factors were extracted.Conclusion:The ancient doctors believed that vitiligo was mostly caused by insect poison,wind evil and damp evil.The main treatments are attacking toxin and killing insects,expelling wind and dredging collaterals,invigorating spleen and benefiting lung,and regulating Qi and blood.Contemporary doctors believe that vitiligo is mostly caused by visceral dysfunction,and the treatment is mainly based on tonifying kidney and lung,invigorating spleen and stomach,expelling wind and dredging collaterals,and promoting blood circulation and removing blood stasis.
vitiligoancient and modernassociation ruleslatern structure modelmedication law
万方数据
维普
