首页|多指标正交试验优化损伤中期口服液的提取工艺

多指标正交试验优化损伤中期口服液的提取工艺

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目的:优选损伤中期口服液的最佳提取工艺。方法:在单因素试验的基础上，以加水量、提取时间、提取次数为考察因素，以毛蕊异黄酮葡萄糖苷、橙皮苷、新橙皮苷、柚皮苷含量及收膏率的综合评分作为评价指标进行L9(34)正交试验设计，优选损伤中期口服液的提取工艺。结果:优选出的最佳提取工艺为加水量9倍，提取1 h，提取3次。毛蕊异黄酮葡萄糖苷、橙皮苷、新橙皮苷、柚皮苷的含量分别为36。19、673。91、825。81、903。85 μg/mL，收膏率为32。28％，综合得分为99。19分。结论:优选的提取工艺重复性好，工艺稳定可靠，为该制剂生产的高效提取提供了理论依据。
0ptimization of Extraction Process in Sunshang Zhongqi 0ral Liquid(损伤中期口服液)by Multi-Index Orthogonal Test
Objective:To optimize the optimal extraction process for Sunshang Zhongqi oral liquid.Methods:The water addition,extraction time and extraction times were used as factors,and the content of galycosin 7-O-β-D-glucopyranoside,hesperidin,neohesperidin,naringin and extract yield were used as the evaluation indexes.On the basis of single factor experiment,L9(34)orthogonal experiment was designed to optimize the extraction process of Sunshang Zhongqi oral liquid.Results:The optimum extraction process was determined to add nine times of water,extract for one hour and extract for three times.The average contents of galycosin 7-O-β-D-glucopyranoside,hesperidin,neohesperidin and naringin were 36.19 μg/mL,673.91 μg/mL,825.81 μg/mL and 903.85 μg/mL,respectively.The average paste yield was 32.28％and the combined score was 99.19.Conclusion The optimized extraction process has good repeatability,stability and reLiability,which provides a basis for the efficient extraction of the preparation in mass production.

Sunshang Zhongqi orall liquidextraction technologygalycosin 7-O-β-D-glucopyranosidehes-peridinneohesperidinnaringinorthogonal test

何清华、徐伟、杨云芝、范润勇、周茜

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南充市中医医院,四川 南充 637000

筋骨病中医药防治南充市重点实验室,四川 南充 637000

损伤中期口服液 提取工艺 毛蕊异黄酮葡萄糖苷 橙皮苷 新橙皮苷 柚皮苷 正交试验

四川省科技计划项目南充市科技局计划项目南充市科技局计划项目

2021YFS027022ZXKTYJ001222YYJCYJ0062

2024

10.13862/j.cn43-1446/r.2024.03.010

中医药导报
湖南省中医药学会 湖南省中医管理局

中医药导报

CSTPCD
影响因子：0.952
ISSN：1672-951X
年,卷(期)：2024.30(3)
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