Preparation and In Vitro Release of Shuanghuangbu Thermosensitive Gel(双黄补温敏凝胶)
Objective:To prepare Shuanghuangbu thermosensitive gel(双黄补温敏凝胶)and investigate its release behavior in vitro.Methods:With the extraction time,solid-liquid ratio and the extraction times as the influencing factors,and the comprehensive score of baicalin and berberine hydrochloride contents as the evaluation index,the extraction process was optimized by orthogonal test.Optimize the formulation process by taking the amount of matrix as the influencing factor and the gelation temperature as the evaluation indicators.Finally,the in vitro drug release behavior was investigated by the dialysis bag method.Results:The optimal extraction processes were as follows:60％ethanol as extraction solvent,extraction time of 0.5 hour,the solid-liquid ratio of 1∶20(m/V),and extraction number of 3 times.The best prescription of Shuanghuangbu thermosensitive gel(双黄补温敏凝胶)were P407 17.0％,P188 1.0％,0.7％extract and the gelation temperature was 34.3 ℃.The drug release of baicalin conforms to the Higuchi equation,and the release of Berberine hydrochloride conforms to the first-order kinetic equation.Conclusion:The preparation of Shuanghuangbu thermosensitive gel(双黄补温敏凝胶)is stable and feasible,which can provide a new dosage form for the development of Shuanghuang-bu(双黄).
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