0bservation on the Clinical Efficacy of Zhuang Medicine Shiduqing Lotion(湿毒清洗剂)in the Treatment of Eczema(Damp-Heat Immersion Syndrome)
Objective:To observe the clinical efficacy of Zhuang medicine Shiduqing Lotion(湿 毒清洗剂)in the treatment of eczema(damp-heat immersion syndrome).Methods:Eighty patients with eczema(damp-heat immersion syndrome)who visited Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from April 2021 to September 2022 were selected and divided into two groups,40 cases in each according to the random number table method.The treatment group was treated with Zhuang medicine Shiduqing lotion wet compress,and the control group was treated with Compound Huangbai Liquid(复 方黄柏 液)wet compress.Both groups were treated for 14 days as a course of treatment.After one course of treatment,the total clinical efficiency,pre-and post-treatment TCM syndrome score,eczema area and severity index(EASI),pruritus score,dermatological quality of life index(DLQI)score,and serum IgE,TNF-α,IL-4 and IL-6 expression levels were compared between the two groups.Results:After treatment,the total clinical efficiency of the treatment group and the control group were 83.33％(30/36)and 54.29％(19/35),respectively,and the treatment group was better than the control group(P＜0.05).After treatment,the TCM syndrome scores,EASI scores,pruritus scores,and DLQI scores in two groups were decreased when compared with those before treatment(P＜0.01),and the TCM syndrome scores,EASI scores,and DLQI scores in the treatment group were lower than those in the control group(P＜0.05).After treatment,the serum levels of IgE,TNF-α,IL-4,and IL-6 in two groups were significantly decreased(P＜0.05),and the serum levels of IgE,TNF-α,and IL-6 in the treatment group were significantly lower than those in the control group(P＜0.05).Conclusion:Zhuang medicine Shiduqing lotion has a good clinical effect in the treatment of eczema(damp-heat immersion syndrome),and can significantly reduce the levels of inflammatory factors IgE,TNF-α,IL-6 and IL-4 in the serum of patients,which may be one of the mechanisms of Zhuang medicine Shiduqing lotion in the treatment of eczema(damp-heat immersion syndrome).
eczemadamp-heat immersion syndromeShiduqing LotionZhuang medicineCompound Huangbai Liquidinflammatory factorsclinical research
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