Application on the Intervention with Epicardial Adipose Tissue for Heart Failure with Preserved Ejection Fraction Based on the"Treating Pathogenic Accumulation with Dissipation"
Application on the Intervention with Epicardial Adipose Tissue for Heart Failure with Preserved Ejection Fraction Based on the"Treating Pathogenic Accumulation with Dissipation"
Heart failure with preserved ejection fraction(HFpEF)is a clinical syndrome characterized by increased left ventricular filling pressure at rest or exercise and the appearance of symptoms or signs of heart failure.It has been well established that epicardial adipose tissue(EAT)plays a critical role in the development of HFpEF,and there is no specific treatment for this condition.From the perspective of"accumulation"disease,it was found that microvascular inflammation,substrate utilization,and energy metabolism were the core patho-genesis of HFpEF combined with EAT.Based on the"treating pathogenic accumulation with dissipation"theory,this article explored the positive therapeutic effect of HFpEF by dispersing knot to reducing inflammatory response,maintaining myocardial energy homeostasis,and inhibiting myocardial fibrosis.
关键词
射血分数保留型心力衰竭/"结者散之"/中医/心外脂肪组织
Key words
heart failure with preserved ejection fraction/"treating pathogenic accumulation with dissipation"/Chinese medicine/extracardiac adipose tissue
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