针刺联合膈下逐瘀汤治疗原发性痛经气滞血瘀证的疗效观察

Curative Effect of Acupuncture Combined with Gexia Zhuyu Decoction(膈下逐瘀汤)on Patients with Primary Dysmenorrhea of Qi-Stagnation and Blood Stasis Type

孙梦 ¹田丽颖 ²程晓嫚 ²张芳芳¹

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作者信息

1. 安徽中医药大学,安徽合肥 230031
2. 安徽中医药大学第二附属医院/安徽省针灸医院,安徽合肥 230061
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摘要

目的:探讨针刺联合膈下逐瘀汤治疗原发性痛经气滞血瘀证的临床疗效.方法:将60例原发性痛经气滞血瘀证患者随机分为治疗组与对照组各30例.对照组患者予布洛芬治疗,治疗组患者在对照组基础上予针刺联合膈下逐瘀汤治疗,两组患者从经期前5 d开始治疗,连续治疗10 d,共治疗3个月经周期.比较两组患者临床疗效,评价治疗前后中医证候评分及疼痛视觉模拟评分(VAS),检测治疗前后血清前列腺素(PG)E2与PGF2α水平,评价不良反应发生情况.结果:治疗组疗效优于对照组,差异有统计学意义(P＜0.05).两组患者治疗后中医证候评分、VAS评分均低于治疗前(P＜0.05);第2、3个月经周期两组比较,治疗组患者中医证候评分、VAS评分均低于对照组(P＜0.05).两组患者治疗后血清PGE2水平均高于治疗前,血清PGF2α水平均低于治疗前,差异均有统计学意义(P＜0.05);治疗组患者治疗后血清PGE2水平高于对照组,血清PGF2α水平低于对照组,差异均有统计学意义(P＜0.05).两组患者不良反应发生情况比较,差异无统计学意义(P＞0.05).结论:针刺联合膈下逐瘀汤治疗原发性痛经气滞血瘀证疗效显著,可缓解疼痛,且具有良好的安全性.

Abstract

Objective:To explore the clinical curative effect of acupuncture combined with Gexia Zhuyu Decoction(膈下逐瘀汤)on patients with primary dysmenorrhea of qi-stagnation and blood stasis type.Methods:A total of 60 patients with primary dysmenorrhea with qi-stagnation and blood stasis syndrome were randomly divided into a treatment group and a control group,with 30 cases in each group.The patients in control group were treated with ibuprofen,while the treatment group were treated with acupuncture combined with Gexia Zhuyu Decoction on the basis of the control group.The two groups of patients started treatment 5 days before menstruation and continued treatment for 10 days,for a total of 3 menstrual cycles.The clinical curative effect was compared between the two groups.The scores of TCM symptoms and visual analogue scale(VAS)were evaluated before and after treatment.The levels of serum prostaglandin(PG)E2 and PGF2α were detected before and after treatment,and the occurrence of adverse reactions was evaluated.Results:The curative effect of treatment group was better than that of control group(P＜0.05).After treatment,scores of TCM symptoms and VAS were decreased in both groups(P＜0.05).During the second and third menstrual periods,scores of TCM symptoms and VAS in treatment group were lower than those in control group(P＜0.05).After treatment,level of serum PGE2 was increased,while level of serum PGF2α was decreased in both groups(P＜0.05).After treatment,PGE2 in treatment group was higher than that in control group,while PGF2α was lower than that in control group(P＜0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(P＞0.05).Conclusion:The curative effect of acupuncture combined with Gexia Zhuyu Decoction is significant on patients with primary dysmenorrhea of qi-stagnation and blood stasis type,which can improve arterial blood flow and relieve pain,with good safety.

关键词

原发性痛经/气滞血瘀证/针刺/膈下逐瘀汤/布洛芬

Key words

primary dysmenorrhea/qi-stagnation and blood stasis type/acupuncture/Gexia Zhuyu decoction/ibuprofen

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基金项目

全国名老中医药专家传承工作室建设项目田丽颖传承工作室项目(国中医药人教函202275号)

安徽省省级重点中医专科建设项目(十三五)(卫办秘2016680号)

出版年

2024

中医药导报

湖南省中医药学会湖南省中医管理局

中医药导报

CSTPCD

影响因子：0.952

ISSN：1672-951X

参考文献量35

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