Clinical Observation on the Treatment of Vascular Dementia after Cerebral Infarction by Fuzheng Huatan Tongluo Decoction(扶正化痰通络汤)
Objective:To observe the effects of Fuzheng Huatan Tongluo Decoction(扶正化痰通络汤,FZHTTLD)on cognitive function scores,quality of life and sleep,depression and anxiety levels in patients with post-cerebral infarction vascular dementia(VaD).Methods:A total of 65 VaD patients in the neurology departments of Liuzhou Traditional Chinese Medical Hospital from October 2020 to October 2022 were selected and divided into control group(33 cases)and treatment group(32 cases).The control group was treated with Western medicine,taking donepezil hydrochloride tablets and nimodipine tablets daily,while the treatment group was additionally given FZHTTLD on the basis of the control group,with a course of three months.The Mini-Mental Status Examination(MMSE),Ability of Daily Living Scale(ADL),Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),and Pittsburgh sleep quality index(PSQI Index)of the two groups were evaluated and compared.Results:There were 3 cases of dropout in the control group and 2 cases of dropout in the treatment group,with a total of 30 patients in each group included in the study.After treatment,the MMSE score,ADL score,HAMA score,HAMD score,and PSQI index score of the two groups were significantly different from before treatment(P＜0.05).The MMSE score,ADL score,and PSQI index score of the treatment group were higher than those of the control group after treatment,while the HAMA score and HAMD score were lower than those of the control group,and the differences were statistically significant(P＜0.05).The total effective rate of the treatment group was higher than that of the control group(P＜0.05).Conclusion:For patients with post-cerebral infarction VaD who meet the traditional Chinese medicine syndrome of spleen and kidney deficiency,phlegm and blood stasis blocking the collaterals,oral administration of donepezil hydrochloride tablets and nimodipine tablets combined with FZHTTLD has definite clinical efficacy,and it can significantly improve patients'cognitive function,anxiety and depression,and improve patients'daily living ability and sleep quality.
万方数据
维普
