Analysis on the Medication Rules of Chinese Medicine Master PAN Minqiu in the Treatment of Primary Liver Cancer Based on Bioinformatics
Objective:To analyze the medication characteristics of PAN Minqiu's treatment of primary liver cancer and provide reference for the diagnosis and treatment of primary liver cancer in traditional Chinese medicine.Methods:Retrospective collection of PAN Minqiu's traditional Chinese medicine prescriptions for the treatment of primary liver cancer.The database was established and analyzed by bioinformatics.Results:A total of 88 prescriptions were included,involving 86 medicinal flavors.High-frequency drugs included Dang shen(Codonopsis Radix)/Renshen(Ginseng Radix),Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Baihuasheshecao(Oldenlandiae Diffusae Herba),and Nvzhenzi(Ligustri Lucidi Fructus).The medicinal properties were mainly mild,warm,and cold,and the flavors of medicines were mainly sweet,bitter,and pungent.The main meridians were spleen,liver,lung,and kidney.Through complex network analysis,the core prescription was obtained:Baizhu(Atractylodis Macrocephalae Rhizoma),Gancao(Glycyrrhizae Radix),Fuling(Poria),Baihuasheshecao(Oldenlandiae Diffusae Herba),Nvzhenzi(Ligustri Lucidi Fructus),Lingzhi(Ganoderma),Banzhilian(Scutellariae Barbatae Herba),Chonglou(Paridis Rhizoma),and Gouqizi(Lycii Fructus),with 269 effective components for treating primary liver cancer,7 core gene targets,and 9 important pathways.Conclusion:The main treatment method used by Chinese medicine master PAN Minqiu in the treatment of liver cancer were strengthening the spleen and tonifying Qi,removing blood stasis and softening hardness,clearing heat and detoxifying.The core pre-scription may be related to anti-tumor,immune regulation,and improvement of endocrine functions.
liver cancersyndrome differentiation and treatmentChinese medicine masterPAN Minqiumedication rulesbioinformatics
万方数据
维普
