Analysis on the Traditional Chinese Medicine Diagnosis and Treatment Rules of Central Precocious Puberty Based on the Traditional Chinese Medicine Inheritance Computing Platform System
Objective:To explore and analyze the diagnosis and treatment rules of traditional Chinese medicine in the treatment of central precocious puberty(CPP)based on the Traditional Chinese Medicine Inheritance Computing Platform System(TCMICS),and to provide reference for clinical treatment.Methods:The clinical research literature on the treatment of CPP by oral administration of traditional Chinese medicine(TCM)were retrievedd by computer through CNKI,Wanfang Data Knowledge Service Platform,VIP database,and Chinese Biomedical Literature Service System from the establishment of the database to February 2023,and the modern medical records books of famous authors(published from 2004 to 2021)were manually retrieved to extract TCM prescriptions.Excel software was used to create the prescription data table for Chinese medicine treatment of CPP,and the diagnosis and treatment rules were mined with the help of the TCMICS V3.0.Results:A total of 82 modern medical cases were included,involving 210 prescriptions and 216 flavors of Chinese medicines.Among 82 medical cases of CPP,the syndrome elements of disease location were mainly liver,involving the spleen,uterus,and kidneys.The pathological syndrome is mainly characterized by Yin deficiency,heat,Qi stagnation,and phlegm.The common syndromes types of CPP included Yin deficiency and excessive fire syndrome,liver depression and fire transformation syndrome,phlegm heat internal excess syndrome,phlegm dampness internal obstruction syndrome,and spleen deficiency phlegm dampness syndrome.The drugs with the highest frequency were Zhimu(Anemarrhenae Rhizoma),Huangbai(Phellodendri Cortex),Mudanpi(Moutan Cortex),Shengdihuang(Rehmanniae Radix Exsiccata seu Recens),Chaihu(Bupleuri Radix),and etc.The main effects included clearing heat,tonifying deficiency,promoting diuresis and dampness,regulating Qi,resolving phlegm,relieving cough,and relieving asthma.The four Qi were mainly cold,mild,and warm.The five flavors were mainly bitter,sweet and spicy.The frequency of meridian tropism was mainly based on the liver meridian,followed by the kidney meridian,lung meridian,and spleen meridian.The core medicine pairs included"Zhimu(Anemarrhenae Rhizoma),Huangbai(Phellodendri Cortex)","Zhimu(Anemarrhenae Rhizoma),Shengdihuang(Rehmanniae Radix Exsiccata seu Recens)","Huangbai(Phellodendri Cortex),Mudanpi(Moutan Cortex)","Zhimu(Anemarrhenae Rhizoma),Mudanpi(Moutan Cortex)","Huangbai(Phellodendri Cortex),Shengdi-huang(Rehmanniae Radix Exsiccata seu Recens)".Cluster analysis revealed three core prescriptions,prescription 1 consisting of Baishao(Paeoniae Radix Alba),Chaihu(Bupleuri Radix),Danggui(Angelicae Sinensis Radix),Mudanpi(Moutan Cortex),and Gancao(Glycyrrhizae Radix),prescription 2 consisting of Chaihu(Bupleuri Radix),Zhebeimu(Fritillariae Thunbergii Bulbus),Baishao(Paeoniae Radix Alba),Xiakucao(Prunellae Spica),and Fuling(Poria),and prescription 3 consisting of Zhimu(Anemarrhenae Rhizoma),Huangbai(Phellodendri Cortex),Mu-danpi(Moutan Cortex),Shengdihuang(Rehmanniae Radix Exsiccata seu Recens),and Xiakucao(Prunellae Spica).Conclusion:The TCM treatment for CPP is suitable for tonifying deficiency and purging excess,support right and dispel evil,regulating the liver,spleen,and kidney in harmony,especially focusing on regulating liver Qi.
central precocious pubertytraditional Chinese medicine treatmentdata miningtraditional Chinese medicine inheritance computing platform system