The Effect and Mechanism of Moxibustion Treatment on a Primary Dysmenorrhea Rat Model at the"Shenque"(CV 8)
Objective:To investigate the therapeutic effects and mechanisms of moxibustion on the"Shenque"(CV 8)in primary dysmenorrhea rat model.Methods:A primary dysmenorrhea rat model was established using estradiol benzoate and oxytocin after determining the estrous cycle through vaginal smear tests.Changes in rat body weight,organ index,writhing latency and writhing scores were observed.Various indicators,including serum hormones,prostaglandins and pain-related factors,were measured to compare the efficacy of moxibustion in treating primary dysmenorrhea in rats.Moxibustion methods included smokeless moxibustion and moxibustion with smoke.Results:In general conditions and behavioral tests of rats,the model group showed a significant increase in writhing response compared to the blank group(P＜0.01),indicating a successful modeling.Compared to the model group,both moxibustion groups exhibited slower reductions in body weight,a significant increase in writhing latency and a significant decrease in writhing response(P＜0.05).The writhing inhibition rates in the smokeless moxibustion,moxibustion with smoke and positive drug groups were 54.89％,37.21％and 68.82％,respectively.Compared to the model group,both moxibustion groups showed significant reductions in serum concentrations of estradiol,oxytocin,prostaglandin F2α,and interleukin-6(P＜0.05),while prostaglandin E2 and β-endorphin levels increased significantly(P＜0.05).Conclusion:Moxibustion on the"Shenque"(CV 8)can effectively alleviate primary dysmenorrhea in rats,and the modulation of endocrine hormones,prostaglandins,and pain-related factors may be its potential mechanisms of action.
primary dysmenorrheamoxibustion"Shenque"(CV 8)ratmechanism research
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