The Medication Pattern and Its Mechanism of Chinese Medical Master LI Diangui in the Treatment of Recurrent Aphthous Ulcer Based on Data Mining and Network Pharmacology Analysis
Objective:By using data mining techniques and network pharmacology research methods,this study analyzes the medication patterns of Professor LI Diangui,a master of traditional Chinese medicine,in the treatment of recurrent aphthous ulcer(RAU),screens core prescriptions,and analyzes their potential mechanisms,in order to provide ideas and theoretical basis for clinical treatment of RAU.Methods:The outpatient prescriptions of Professor LI Diangui for treating RAU patients from January 2021 to July 2023 were collected.And SPSS Statistics 26.0 and SPSS Modeler 18.0 analysis software was used to study the medication patterns of the selected traditional Chinese medicine prescriptions.Cytoscape 3.9.1 was used to visualize the complex network,then to determine the core prescription,and analyze its components,targets,and pathways of action for treating RAU through network pharmacology.Results:A total of 156 medical cases were included,and 103 effective traditional Chinese medicine prescriptions were recorded,with a total of 164 traditional Chinese medicines and a total frequency of 2 121 times.The drugs with higher frequency include Huanglian(Coptidis Rhizoma),Shengdihuang(Rehmanniae Radix),Huangqin(Scutellariae Radix),Chaihu(Bupleuri Radix),Qingbanxia(Pinelliae Rhizoma Praeparatum Cum Alumine),Chuanniuxi(Cyathulae Radix),Danzhuye(Lophatheri Herba)and Pugongying(Taraxaci Herba),etc.The medicinal properties are mostly cold and warm,and the medicinal flavors are mainly bitter,sweet,and spicy.The meridians mainly belong to the lung,liver,and stomach.The core prescriptions are determined,including Huanglian(Coptidis Rhizoma),Shengdihuang(Rehmanniae Radix),Huangqin(Scutellariae Radix),Chaihu(Bupleuri Radix)and Qingbanxia(Pinelliae Rhizoma Praeparatum Cum Alumine).The important active ingredients include quercetin,stigmasterol,kaempferol,and biotinyl-4-aminobutyric acid.The key targets include TNF,IL-6,IL-1β,and IFN-γ,key pathways include PI3K-Akt signaling pathway,ACE-RACE signaling pathway,etc.Conclusion:Professor LI Diangui believes that the accumulation of turbid toxins is the core pathogenesis of RAU,and the treatment of RAU is carried out through the methods of clearing heat,dispelling dampness,and detoxifying turbidity.The core prescription may play a role in treating RAU through the PI3K-Akt signaling pathway and ACE-RACE signaling pathway.
万方数据
维普
