Study on Anti-inflammatory Effect and Mechanism of Maoyujin(Curcuma aromatica Salisb)Extract
Objective:To study the anti-inflammatory effect and mechanism of Maoyujin(Curcuma aromatica Salisb)extract.Methods:The mice ear swelling by croton oil,mice toe swelling by egg white,and mice peritoneal capillary permeability by acetic acid were used to observe the anti-inflammatory effect of Maoyujin(Curcuma aromatica Salisb)extract.The acute kidney injury(AKI)of mice was induced by lipopolysaccharide(LPS).The levels of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10)in AKI mice were detected by enzyme-linked immunosorbent assy(ELISA),and TNF-α level in renal tissue and renal coefficient were detected.Results:Compared with blank control group,the high-dose,middle-dose and low-dose of the Maoyujin(Curcuma aromatica Salisb)extract significantly reduced the mice ear swelling by croton oil(P＜0.05 or P＜0.01),reduced the mice toe swelling by egg white for 0.5,1.0,2.0 hours(P＜0.05 or P＜0.01),reduced the mice peritoneal capillary permeability by acetic acid(P＜0.05 or P＜0.01);Compared with model control group,the high-dose,middle-dose and low-dose of the Maoyujin(Curcuma aromatica Salisb)extract significantly decreased the levels of serum TNF-α,IL-6 in AKI mice(P＜0.05 or P＜0.01),increased the levels of serum IL-10(P＜0.05 or P＜0.01),decreased the levels of renal tissue TNF-α and renal coefficient(P＜0.05 or P＜0.01).Conclusion:The Maoyujin(Curcuma aromatica Salisb)extract has significantly anti-inflammatory effect.The mechanism may be involved in decreasing the levels of TNF-α,IL-6,increasing the levels of IL-10,and regulation the imbalance between inflammation and anti-inflammatory.
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