Observation on the Effect of Huatan Tongluo Granule(化痰通络颗粒)in the Treatment of Stable Angina Pectoris with Different TCM Syndromes
Objective:To explore the difference of curative effect of Huatan Tongluo Granule in the treatment of stable angina pectoris(SAP)with different TCM syndromes.Methods:A total of 219 SAP patients with blood stasis syndrome were included and divided into 53 cases of qi deficiency and blood stasis group,63 cases of phlegm and blood stasis group,56 cases of qi stagnation and blood stasis group,and 47 cases of phlegm turbidity blocking group according to TCM syndrome types.Another 50 SAP patients with blood stasis syndrome were included as the control group.All patients received routine treatment,except for the control group,the other patients were treated with Huatan Tongluo Granule on the basis of routine treatment for 4 weeks.The efficacy of TCM syndromes,angina pectoris,cardiac function,lipid metabolism and coagulation function were observed before and after treatment.Results:After treatment,the curative effect of qi deficiency and blood stasis group,phlegm and blood stasis group,qi stagnation and blood stasis group and phlegm turbidity blocking group was better than that of the control group(P＜0.05),and the curative effect of phlegm and blood stasis group and phlegm turbidity blocking group was better than that of qi deficiency and blood stasis group and qi stagnation and blood stasis group(P＜0.05).After treatment,the scores of angina pectoris symptoms in the five groups were lower than those before treatment(P＜0.05),and the scores of angina pectoris symptoms in the qi deficiency and blood stasis group,the phlegm and blood stasis group,the qi stagnation and blood stasis group and the phlegm turbidity blocking group were lower than those in the control group(P＜0.05).The scores of angina pectoris symptoms in the phlegm and blood stasis group and the phlegm turbidity blocking group were lower than those in the qi deficiency and blood stasis group and the qi stagnation and blood stasis group(P＜0.05).After treatment,LVEDD and LVESD in the five groups were lower than those before treatment,and EF and SV were higher than those before treatment(P＜0.05).LVEDD and LVESD in the phlegm and blood stasis group and phlegm turbidity obstruction group were lower than those in the control group,and EF and SV were higher than those in the control group(P＜0.05).Before treatment,the levels of TC,TG and LDL in the phlegm turbidity blocking group and the phlegm and blood stasis group were higher than those in the qi deficiency and blood stasis group,the qi stagnation and blood stasis group and the control group.After treatment,TC,TG and LDL in the five groups were lower than those before treatment,and HDL was higher than that before treatment(P＜0.05).After treatment,FIB and TT in the five groups were lower than those before treatment,and APTT was higher than that before treatment.The levels of FIB and TT in the phlegm and blood stasis group and the phlegm turbidity blocking group were lower than those in the qi deficiency and blood stasis group,qi stagnation and blood stasis group and the control group(P＜0.05).Conclusion:Huatan Tongluo Granule has a certain effect in the treatment of stable angina pectoris with different TCM syndromes.The combined western medicine treatment is better than the single western medicine treatment,and it is more suitable for the two syndromes of phlegm and blood stasis syndrome and phlegm turbidity obstruction syndrome.
stable angina pectoristhoracic obstructionTCM syndromesqi deficiency and blood stasis syndromephlegm and blood stasis syndromeqi stagnation and blood stasis syndromephlegm turbidity blocking syndromeeliminating phlegm and promoting arthralgiaHuatan
万方数据
维普
