Effect of Wubie Fanchun Oral Liquid(乌鳖返春口服液)on Ovarian Function in Patients with Premature Ovarian Insufficiency Based on Propensity Score Matching Method
Objective:To explore the effect of Wubie Fanchun Oral Liquid(乌鳖返春口服液,WBY)on ovarian function in patients with premature ovarian insufficiency based on propensity score matching(PSM)method.Methods:The clinical data of POI patients were collected through the clinical research data collection and management system.The patients in the control group were treated with hormone replacement therapy(HRT),and the patients in the observation group were treated with Wubie Huichun Oral Liquid on the basis of HRT.The PSM method was used to balance confounding factors,and the impact of WBY on ovarian function in POI patients was analyzed.The impact of WBY on ovarian function in POI patients was analyzed through linear regression and ordered logistic regression.Results:A total of 263 POI patients were included in the analysis.(1)Comparison of baseline data and ovarian function indicators between the two groups before and after PSM:A total of 171 cases in the observation group and 92 cases in the control group before PSM.The difference of age,age at menarche,marital status,pregnancy history,delivery history,abortion history,E2,FSH,LH,AMH and AFC between two groups was not statistically significant(P＞0.05).The duration of disease and amenorrhea proportion of the observation group were significantly lower than those of the control group,and the BMI was significantly higher than that of the control group(P＜0.05).Comparing the baseline data of the two groups after PSM,the difference in each indicator was not statistically significant(P＞0.05).(2)Comparison of ovarian function indicators between the two groups after PSM:Compared with the control group,E2,AMH,and AFC in the observation group increased significantly(P＜0.05),while FSH and LH decreased significantly(P＜0.05).(3)The specific impact of WBY on ovarian function indicators:compared with the control group,E2 in the observation group increased by 55.047 ng/L[95％CI(25.136,84.958)],and AMH increased by 0.449 ng/mL[95％CI(0.306,0.592)],FSH decreased by 13.54 mIU/mL[95％CI(-23.702,-3.378)],LH decreased by 5.193 mIU/mL[95％CI(-10.855,0.468)];compared with the control group,the possibility of increasing one AFC in the observation group increased by 3.112 times[OR=3.112,95％CI(0.853,1.975),P＜0.001].(4)Subgroup analysis results.Compared with the control group,Group a(age＜35 years old):E2,AMH,and AFC in the observation group were significantly increased,FSH as well as LH was significantly decreased,the difference was statistically significant(P＜0.05);Group b(age ≥ 35 years old):AMH increased significantly,FSH decreased significantly(P＜0.05),and the difference in E2,LH and AFC had no statistical significance(P＞0.05).(5)Pregnancy outcome:The pregnancy rate in the observation group was 10.96％(8/73),and the live birth rate was 9.59％(7/73);the pregnancy rate in the control group was 6.98％(3/43),and the birth rate was 6.98％(3/43).There was no statistical difference in pregnancy rate and live birth rate between the two groups(P＞0.05).Conclusion:WBY combined with HRT can improve the ovarian function of POI patients of different ages.It is more effective in patients under the age of 35,and the probability of natural pregnancy in patients has an increasing trend.
万方数据
维普
