Objective:To evaluate the clinical efficacy of Modified Zishui Qinggan Decoction in the treatment of depression with liver depression and kidney deficiency.Methods:A total of 72 patients with mild to moderate depression of liver depression and kidney deficiency were randomly divided into experimental group and control group,36 cases in each group.Patients in the experimental group were treated with Modified Zishui Qinggan Decoction combined with fluoxetine,while patients in the control group were treated with fluoxetine alone.The course of treatment was 6 weeks.The Hamilton Depression Scale score and TCM syndrome score were used to evaluate the patient's performance.Results:The antidepressant effect of the experimental group was better than that of the control group(P＜0.05).There were significant differences between the total score of HAMD and the total score of TCM syndromes at the time point and the interaction(P＜0.05).The HAMD total score and TCM symptom score of the two groups at 2,4 and 6 weeks of treatment were lower than those before treatment(P＜0.05).The results of HAMD score showed that compared with the control group,the depression,difficulty falling asleep,somatic anxiety and obsessive-compulsive symptoms of the experimental group were significantly improved,while the work and interest,ability loss and despair were not significantly improved.Conclusion:Modified Zishui Qinggan Decoction combined with fluoxetine is superior to fluoxetine monotherapy in the treatment of mild to moderate depression with liver depression and kidney deficiency.This treatment has excellent efficacy in reducing anxiety and depression symptoms,somatic discomfort and improving sleep quality.
关键词
抑郁症/肝郁肾虚/滋水清肝饮加味方/氟西汀
Key words
depression/liver depression and kidney deficiency/Modified Zishui Qinggan Decoction/fluoxetine
维普
万方数据