摘要
目的:观察壮医临证施护联合水蛭疗法在类风湿关节炎活动期中的短期抗炎止痛及减轻疾病活动度的效果.方法:纳入类风湿关节炎活动期患者120例,采用随机数字表法将患者分为对照组与观察组,每组60例.对照组采用双氯芬酸钠双释放肠溶胶囊治疗,观察组采用壮医临证施护联合水蛭疗法,疗程14 d.观察两组患者治疗前、治疗1周后、治疗2周后关节疼痛评分(目测模拟标尺法VAS)、肿胀评分、DAS28评分及血清学指标(CRP、RF、ESR、PT、PLT)及治疗后临床疗效.结果:治疗后,两组患者关节疼痛(VAS)、关节肿胀数、DAS28评分及血清学指标(CRP、RF、ESR、PT、PLT)均较治疗前明显改善(P＜0.05),且观察组与对照组相比明显改善(P＜0.05);观察组临床总有效率(93.33％)明显高于对照组(53.33％),差异有统计学意义(P＜0.05).结论:壮医临证施护联合水蛭疗法在治疗类风湿关节炎活动期患者时,短期内展现出显著的抗炎止痛效果,并能减轻疾病活动度.
Abstract
Objective:To observe the short-term anti-inflammatory,analgesic,and symptomatic relief effects of Zhuang medicine clinical nursing integrated with leech therapy in patients experiencing the active phase of rheumatoid arthritis.Methods:A total of 120 patients with active rheumatoid arthritis were selected and divide into a control group and an observation group using the random number table method,with 60 patients in each group.The control group received diclofenac sodium double-release enteric-coated capsules,while the observation group received Zhuang medicine clinical nursing combined with leech therapy for a treatment duration of 14 days.The visual analog scale(VAS)scores for joint pain,joint swelling scores,DAS28 scores,and serological indicators(CRP,RF,ESR,PT,PLT)were observed before treatment,1 week after treatment,and 2 weeks after treatment in both groups.The clinical efficacy was evaluated.Results:After treatment,both groups showed significant improvements in joint pain(VAS),joint swelling count,DAS28 scores,and serological indicators(CRP,RF,ESR,PT,PLT)compared to before treatment(P＜0.05).Additionally,the observation group demonstrated more significant improvements compared to the control group(P＜0.05).The clinical total effective rate in the observation group was 93.33％,which was significantly higher than that in the control group of 53.33％(P＜0.05).Conclusions:Zhuang medicine clinical nursing combined with leech therapy exhibits significant short-term anti-inflammatory,analgesic,and disease activity-reducing effects in patients with active rheumatoid arthritis.
基金项目
广西中医药大学面上项目(2020MS061)
广西中医药重点培育学科(GZXK-P-20-14)
广西国际壮医医院院级课题(2019010)
维普
万方数据