Research Progress on the Molecular Mechanism of Traditional Chinese Medicine for Promoting Blood Circulation and Removing Blood Stasis for the Prevention and Treatment of Coronary Microvascular Dysfunction
Research Progress on the Molecular Mechanism of Traditional Chinese Medicine for Promoting Blood Circulation and Removing Blood Stasis for the Prevention and Treatment of Coronary Microvascular Dysfunction
Coronary microvascular dysfunction(CMD)refers to a clinical syndrome characterized by structural and functional alterations in the coronary microcirculation,leading to impaired coronary blood flow(CBF)and ultimately resulting in myocardial ischemia.In clinical practice,traditional Chinese medicine often employs blood-activating and stasis-removing herbs(BAST)to treat CMD.These BAST are believed to exert their therapeutic effects on CMD through various molecular mechanisms,including improving microvascular endothelial relaxation and constriction functions,promoting microvascularneoangiogenesis,inhibiting the abnormal proliferation and migration of vascular smooth muscle cells(VSMCs),suppressing inflammatory responses,regulating apoptosis in cardiac cells,inhibiting oxidative stress,and improving platelet activation and aggregation.
关键词
冠状动脉微循环障碍/分子机制/中药/活血化瘀/信号通路
Key words
coronary microvascular dysfunction/molecular mechanism/traditional chinese medicine/blood-activating and stasis-removing/signaling pathway
维普
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