Research Progress on the Molecular Mechanism of Traditional Chinese Medicine for Promoting Blood Circulation and Removing Blood Stasis for the Prevention and Treatment of Coronary Microvascular Dysfunction
Coronary microvascular dysfunction(CMD)refers to a clinical syndrome characterized by structural and functional alterations in the coronary microcirculation,leading to impaired coronary blood flow(CBF)and ultimately resulting in myocardial ischemia.In clinical practice,traditional Chinese medicine often employs blood-activating and stasis-removing herbs(BAST)to treat CMD.These BAST are believed to exert their therapeutic effects on CMD through various molecular mechanisms,including improving microvascular endothelial relaxation and constriction functions,promoting microvascularneoangiogenesis,inhibiting the abnormal proliferation and migration of vascular smooth muscle cells(VSMCs),suppressing inflammatory responses,regulating apoptosis in cardiac cells,inhibiting oxidative stress,and improving platelet activation and aggregation.
coronary microvascular dysfunctionmolecular mechanismtraditional chinese medicineblood-activating and stasis-removingsignaling pathway
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维普
