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牛病毒性腹泻抗体制剂的制备及其应用研究

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抗体制剂是牛病毒性腹泻最为有效的临床治疗药剂,但现有制剂易在瘤胃中降解而药效不佳。本研究利用抗体包被技术开发了一种能有效避免瘤胃降解的牛病毒性腹泻抗体制剂的制备方法,对抗体制剂筛选的6个组方体系进行稳定性、安全性和药效综合考察,表明体系1(抗体5。0 g、卵磷脂20。0 g、聚乙二醇800 15 g、β-谷甾醇1。0 g、鞣云实素3。0 g、吐温-20 15。0 g、去离子水41。0 g)为最优组方,临床疗效显著高于普通抗体制剂。该制剂具有稳定性强和安全性高的特点,能有效解除瘤胃液对口服抗体的影响,促进其在肠道中的高效吸收和利用,对临床防控牛病毒性腹泻有着重要意义。
Preparation and Application of Antibody Preparation for Bovine Viral Diarrhea
Antibody preparations are the most effective clinical treatment for bovine viral diarrhea,but existing preparations are prone to degradation in the rumen and have poor efficacy.This study developed a preparation meth-od for Bovine viral diarrhea antibody formulations that can effectively avoid rumen degradation using antibody en-capsulation technology.Conduct a comprehensive evaluation of the stability,safety,and efficacy of the 6 prescrip-tion systems screened for antibody preparations.The results indicate that System 1(antibody 5.0g,lecithin 20.0g,polyethylene glycol 800 15g,β-Sitosterol 1.0g,tanyunsu 3.0g,tween-20 15.0g,deionized water41.0)is the op-timal combination.The clinical efficacy is significantly higher than that of ordinary antibody preparations.This prep-aration has the characteristics of strong stability and high safety,it can effectively relieve the influence of gastric juice on oral antibodies,promote its efficient absorption and utilization in the intestine.It is of great significance for the clinical prevention and control of Bovine viral diarrhea.

cattlebovine viral diarrheaantibodiespreparation

项朝荣、郑虎、马超锋、徐华

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济源市动物疫病预防控制中心,河南济源 459000

罗山县畜牧兽医技术服务中心,河南罗山 464200

信阳市畜牧兽医技术服务中心,河南信阳 464000

牛病毒性腹泻 抗体 制剂

河南省科技攻关计划

212102110351

2024

中国牛业科学
西北农林科技大学 中国畜牧兽医学会养牛学分会 中国良种黄牛育种委员会

中国牛业科学

影响因子:0.32
ISSN:1001-9111
年,卷(期):2024.50(1)
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