Study on the preparation of zeolite solidified volatile oil and evaluation of the function of drug loaded zeolite
Objective To screen the preparation process of volatile oil loaded on zeolite,evaluate its performance,and discuss the feasibility of using zeolite to solidify volatile oil.Methods According to the drug loading effect,the preparation process and drug/adjuvant ratio of zeolite supported volatile oil were optimized;the morphology of zeolite and drug loaded zeolite was analyzed by scanning electron micro-scope;the loss rate of volatile oil and drug loaded zeolite at high temperature and evaluate their stability were investigated;finally,the release of drug loaded zeolites with different drug/adjuvant ratios in the environment of 30℃and 75%humidity was investigated.Results The preparation of drug-loaded zeolite by grinding method was simple and rapid,and the optimal ratio of zeolite supported volatile oil was 1:1.75.The results of scanning electron microscope showed that the size of zeolite was 2～6 μm,and the morphology of zeolite wasn't changed by grinding.At high temperature,zeolite molecular sieve can improve the stability of active components in volatile oil and slow down the volatilization of volatile oil.The larger the drug/adjuvant ratio,that is,the smaller the proportion of zeolite,the better effect of zeolite solidified the volatile oil,and the slower the volatilization rate.Conclusion Zeolite can adsorb and solidify the volatile oil,and the preparation process of drug-loaded zeolite is simple,which can effectively improve the stability of volatile oil.The different release rates of drug-loaded zeolite with different drug/adjuvant ratio can meet the needs of different application scenarios,and has a good development prospect.
NETL
NSTL
万方数据
维普
