Discussion on the prescription regularities and differences of ancient and modern physicians in treating breast cancer based on data mining
Objective Probe into the prescription regularities and differences of ancient and modern physicians in the treatment of breast cancers.Methods Dingxiu Ancient Books Full Text Retrieval Platform,Database of Basic Ancient Books of Traditional Chinese Medicine(Bogu Tongru)and the ancient and modern medical record cloud platform were searched for related ancient prescriptions.CNKI,Wanfang Data,and VIP databases were search for modern prescriptions for the treatment of breast cancer published up to September,2022.The ancient and modern medical record cloud platform was used to establish a database to conduct frequency statistics,nature,taste and meridian tropism,correlation analysis,complex network analysis and cluster analysis on the filtered Chinese medicines.Results The most frequently used for breast cancer in both ancient and modern prescriptions include the herbs of angelica sinensis,licorice,paeoniae radix alba,poria cocos and atractylodes macrocephala koidz.In ancient and modern prescriptions,the herbs with warm,mild and cold natures were used more,while the herbs with sweet,bitter and spicy taste were used more.Most herbs entered the spleen,liver and lung meridians in both ancient and modern prescriptions.The most common medical combination was paeoniae radix alba and angelica sinensis in ancient prescriptions,while poria cocos and atractylodes macrocephala koidz in modern prescriptions.The key herb combination of ancient prescriptions for breast cancer was'atractylodes macrocephala koidz,poria cocos,paeoniae radix alba,angelica sinensis,ligusticum chuanxiong,radix et rhizoma ginseng,rehmannia glutinosa libosch,licorice',while'atractylodes macrocephala koidz,astragali radix,poria cocos,angelica sinensis,paeoniae radix alba,radix bupleuri,radix codonopsise'in modern prescriptions for breast cancer.Cluster analysis shows that five new prescriptions are obtained from ancient prescriptions,while three new prescriptions are obtained from modern prescriptions.Conclusion The rule of ancient and modern prescriptions for breast cancer was'solidifying vital qi'.On this basis,ancient physicians tended to invigorate spleen and benefit qi,while modern physicians tended to sooth liver and strengthen spleen.
breast cancerancient physiciansmodern physicianstraditional Chinese medicinedata miningmedication regularitydifferencessolidifying vital qi
NETL
NSTL
万方数据
维普
