Research progress on the mechanism of Tianma Gouteng decoction in preventing and treating nervous system diseases
Nervous system diseases often have complex causes,various symptoms and refractory diseases.Tianma Gouteng decoction is widely used in the prevention and treatment of nervous system diseases by clinical doctors for calming liver and reducing adverse reactions.However,due to the complex composition of traditional Chinese medicine compound and the interaction between them,the mechanism of Tianma Gouteng decoction in preventing and treating neurological diseases has not been completely clear,and the existing research results are messy.Therefore,this paper reviewed the basic research on Tianma Gouteng decoction in the past ten years.The study found that Tianma Gouteng decoction can inhibit the in-flammatory response by inhibiting the nuclear factor kappa B/Toll-like receptor 4 signaling pathway and in-hibiting the expression of related inflammatory factors;it can activate Klotho/fibroblast growth factor 23,nuclear factor E2-related factor 2/heme oxygenase-1 pathway,inhibit N-methyl-D-aspartate receptor/extracellular regulated protein kinase signaling pathway,and enhance mitochondrial fusion protein 2 expression to improve oxidative stress injury;it can induce lipid metabolism,inhibit neuroinflammation,regulate autophagy,and prevent dopamine neuron degeneration to play a neuroprotective role;it can inhibit apoptosis by regulating mitochondrial function,down-regulating N-methyl-D-aspartate 2B receptor expression,up-regulating B-cell lymphoma-2 protein,and activating c-Jun N-terminal kinase signaling pathway.And the regulation of 5-hydroxytryptamine neurotransmitter levels and other mechanisms play a role in the prevention and treatment of neurological diseases.This article reviews the mechanism of Tianma Gouteng decoction in preventing and treating nervous system diseases,in order to provide references for the subsequent pharmacological research and clinical application of this prescription.
Tianma Gouteng decoctionneurological diseasesmechanism of actionresearch progress
NETL
NSTL
万方数据
维普
