Research progress of salidroside in the prevention and treatment of eye diseases
Salidroside is a kind of phenylpropanoid glycoside isolated from rhodiola rosea.It has broad-spectrum pharmacological properties such as anti-hypoxia,anti-oxidation,anti-inflammation,nerve protection,anti-fatigue,anti-aging and immune regulation.Salidroside has a multi-target-multi-pathway global regulatory characteristic,which protects retinal vascular endothelial cells,retinal pigment epithelial cells and Muller cells in diabetic retinopathy by activating PI3K/AKT and AMPK pathways,Bcl-2/Bax signaling pathway and the activity of endogenous antioxidant enzymes,and COX2/PGE2 signaling pathway.Activation and regulation of TGF-β2 signaling pathway,PI3K/AKT and Wnt/b-catenin pathway,thereby inhibiting the apoptosis of trabecular network cells and ganglion cells,and regulating the stability of intraocular pressure;Activation of AKT/GSK-3 β signaling pathway inhibited the oxidative damage of retinal pigment epithelial cells in age-related macular degeneration,decreased the expression levels of vascular endothelial growth factor and hypoxia-inducible factor-1,and inhibited the formation of choroidal neovascu-larization.Exert antioxidant activity and protect the epithelial cells of cataract lens from oxidative damage;Ameliorating scleral hypoxia caused by myopia;In addition,by activating AMPK-SIRT-1 signaling pathway to promote autophagy,the oxidative stress of the body can be inhibited,and the oxidative damage of corneal epithelial cells caused by dry eye can be alleviated.The application of salidroside in ophthalmology is becoming more and more extensive.In this paper,the latest research progress of salidroside in the treatment of ophthalmic diseases is reviewed.
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