Review in pharmacological mechanism of Acorus tatarinowii the prevention and treatment vascular dementia
Vascular dementia is one of the most prevalent types of dementia in China and even the world.Its pathogenesis is complex and there is no specific drug for clinical treatment,which seriously affects human life and health.Research has shown that Acorus tatarinowii is a core traditional Chinese medicine in the treatment of vascular dementia,which has the effect of opening orifice and clearing phlegm,awakening the mind and intelligence,turning dampness and appetizing,and has significant advantages in the prevention and treatment of vascular dementia.Rhocalamus has a complex chemical com-position,with its main active components α-asaryl etherr and β-asaryl ether ether,becoming a research hotspot because of their extensive pharmacological activities.The plant and its active components are known to regulate the permeability of the blood-brain barrier to promote the blood-brain barrier;scavenge free radicals and improve antioxidants to resist oxidative stress;regulate inflammatory factors to resist inflammation;regulate neuroplasticity by removing β-amyloid protein;regulate neurotransmitters to protect cholinergic nerves;and protect the hippocampus neurons against vascular dementia.This paper reviews the pharmacological mechanisms of resistance-vascular dementia to provide theoretical basis and evidence-based support for its application.
万方数据
维普
