Autophagy is a programmed cell degradation pathway mediated by lysosomes.Through degradation and reabsorption,autophagy plays an important role in maintaining cell homeostasis,eliminating toxic substances in cells and balancing metabolic energy.Autophagy is involved in many aspects of ulcerative colitis(UC).Studies have shown that autophagy can improve intestinal mucosal barrier function,regulate immune inflammatory response,regulate intestinal flora,and reduce oxidative stress damage.At present,targeted treatment of UC by intervening autophagy has become the frontier direction of research.It is reported that many Chinese medicine monomers and compounds with high curative effect on UC participate in the regulation of autophagy by regulating autophagy-related proteins,autophagy-related genes,autophagy signal pathways,cytokines and other aspects.
关键词
溃疡性结肠炎/自噬/中药/作用机制/黏膜屏障/免疫炎症/菌群/氧化应激
Key words
ulcerative colitis/autophagy/Chinese medicine/mechanism of action/mucosal barrier/immune inflammation/flora/oxidative stress
维普
万方数据