Exploration of themechanism of Xuefu Zhuyu Decoction in treating coronary heart disease and ischemic stroke with the concept of'Different Diseases with the Same Treatment'based on network pharmacology and molecular docking technology
Objective To explore the mechanism of treating coronary heart disease(CHD)and ischemic stroke(IS)in Xuefu Zhuyu Decoction by network pharmacology combined with molecular docking technology.Methods The active ingredients and target of 11 herbs of Xuefu Zhuyu Decoction were searched in TCMSP database,and the official name of the target was matched through Uniprot database.CHD and IS-related disease targets were obtained from OMIM,DrugBank,DisGNET,TTD and GeneCards databases,and intersection targets were selected to construct a'single drug—common target—disease'network.Centiscape plug-in was used to screen key targets,and MetaScape database was used for GO functional analysis and KEGG pathway enrichment analysis.Molecular docking prediction was performed by AutoDockTools-1.5.6.Results 192 active ingredients and 394 targets of Xuefu Zhuyu Decoction were obtained after screening.The pathways related to CHD and IS are lipid and atherosclerosis,HIF-1,relain and NF-κB signaling pathways,which are mainly related to biological processes such as lipid metabolism,inflammatory response,oxidative stress,angiogenesis and apoptosis.Luteolin,kaempferol and naringenin were well combined with target proteins AKT1,ALB and INS.Conclusion Based on the method of network pharmacology,Xuefu Zhuyu Decoction was found to treat coronary heart disease and ischemic stroke through multi-target and multi-pathway,and several components showed good activity.It may improve the state of ischemia and hypoxia by anti-oxidation,anti-inflammation,inhibiting apoptosis,regulating hormone level,promoting angiogenesis and so on,and play the role of'treating different diseases together'.
Xuefu Zhuyu Decoctioncoronary heart diseaseischemic strokedifferent diseases should be treated togethernetwork pharmacology
NETL
NSTL
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