Research on the mechanism of acupuncture on insomnia
Long-term illness can lead to a variety of complications.Acupuncture can adjust insomnia,anxiety,depression and other complications from multiple perspectives.By analyzing the basic research in recent years,there are the following mechanisms for acupuncture treatment of insomnia.(1)Regulation of the content of neurotransmitters,up-regulating the content of 5-hydroxytryptamine(5-HT)and γ-aminobutyric acid(GABA),and down-regulating the content of dopamine(DA),norepinephrine(NE)and glutamate(Glu),so as to balance the sleep-wake system to prolong sleep time and reduce wakefulness.(2)Regulation of the hypothalamic-pituitary-adrenal axis(HPA axis)and related hormones,by down-regulating the content of corticotropin releasing hormone(CRH),corticosterone(CORT),adre-nocorticotropic hormone(ACTH),thereby inhibiting the overactive HPA axis to improve insomnia symptoms and relieve anxiety,depression and other emotional disorders.(3)Regulation of the content of cytokines.Acupuncture can participate in the regulation of the central nervous system by up-regulating the content of interleukin-1(IL-1)and tumor necrosis factor(TNF),and up-regulating the content of 5-HT from the side to prolong sleep time and reduce awakening.(4)Regulation of the function of brain regions.Acupuncture can regulate the function of related brain regions such as emotion,cognition and memory,and improve the complications such as anxiety,depression and memory loss in patients with long-term insomnia.(5)Regulation of cation-chloride cotransporters(CCCs),by changing the expression of CCCs,regulating intracellular and extracellular chloride concentration to regulate sleep.
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