Research progress on the intervention of aging through the mitochondrial pathway by kidney-tonifying traditional Chinese medicine
Mitochondriadis pivotal in cellular energy metabolism and the regulation of cellular functions.As individuals age,there is a gradual deterioration in mitochondrial function,resulting in diminished cellular activity and expedited aging processes.The decline in mitochondrial function constitutes a noteworthy contributor to the aging phenomenon,and the utilization of kidney-tonifying herbal medicines can effectively enhance both the quantity and functionality of mitochondria through diverse mechanisms,thereby retarding the aging process.Firstly,herbal medicines with kidney-tonifying properties have the ability to modulate the mitochondrial antioxidant defense system,thereby facilitating the removal of reactive oxygen species,enhancing the redox capacity of mitochondria,and mitigating mitochondrial oxidative stress.Secondly,these herbal medicines can regulate mitochondrial autophagy,leading to the elimination of impaired mitochondria and the preservation of mitochondrial homeostasis.Thirdly,it is worth noting that kidney-tonifying Chinese herbal medicine has the potential to stimulate mitochondrial biosynthesis,thereby augmenting mitochondrial function and stability.Lastly,it can induce mitochondrial fusion and fission,which play a crucial role in maintaining mitochondrial equilibrium and preserving optimal cellular function.The primary objective of this review is to elucidate the underlying mechanisms,thereby establishing a more comprehensive theoretical foundation for the management and prevention of age-related ailments.
kidney-tonifying Chinese medicinal herbsmitochondriaagingoxidative stressautophagybiogenesisfusion and fission
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