Research progress on the mechanism of acupuncture in the treatment of myasthenia gravis
Myasthenia gravis is a chronic disease that is prolonged and difficult to cure,and acupuncture can effectively reduce the symptoms of myasthenia gravis,delay the progression of the disease,and improve the quality of daily life.In this paper,by reviewing the literature related to clinical studies and animal experiments on acupuncture treatment of myasthenia gravis in recent years,we summarized that acu-puncture can down-regulate the level of AChR-Ab and up-regulate the expression level of AchR,which can enhance the function of AchR,ensure the normalization of neuromuscular signaling,and improve the fatigue skeletal muscle weakness;acupuncture can regulate the CD4+,CD8+T-lymphocytes and B-lymphocytes,reduce pathogenic.Acupuncture can regulate CD4+T lymphocytes and CD8+B lymphocytes,reduce the production of pathogenic autoantibodies and improve the immune dysfunction;acu-puncture can down-regulate the expression of IL pro-inflammatory factors,IFN-γ and TNF-α,and up-regulate the expression level of TGF-β,which induces immune tolerance or delays the immune response and reduces inflammatory response;acupuncture can regulate the level of the complement molecule C3,reduce the formation of membrane attack complexes,and regulate the immune function of the complement system to improve the clinical symptoms of patients with myasthenia gravis.This paper indicated that acupuncture treatment of myasthenia gravis was characterized by multiple pathways,multiple levels and multiple targets.Future studies should further explore the efficacy of acupuncture as a separate treatment in myasthenia gravis.The efficacy of moxibustion intervention in myasthenia gravis should by paid more attention.The related signaling pathways in more depth to explore the specific mechanism of its role should be studied so as to provide a basis and ideas for the future exploration of the mechanism of action of acupuncture in the treatment of myasthenia gravis.
acupuncturemyasthenia gravismechanism of actionresearch progressau-toantibodylymphocytecytokinecomplement
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