基于线粒体代谢的针灸治疗慢性疲劳综合征的研究进展

Research progress of acupuncture treatment of chronic fatigue syndrome based on mitochondrial metabolism

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中文摘要：针灸治疗慢性疲劳综合征(chronic fatigue syndrome,CFS)效果确切,其机制研究主要集中于控制炎性反应、调节免疫反应、对抗过氧化应激机制、调节神经内分泌功能等方面,对于调节线粒体代谢方面尚且不足.基于此本文检索了基于线粒体代谢机制探讨针灸治疗CFS的相关文献,结果显示,针灸调节线粒体功能从而治疗CFS是多层次、多靶点共同作用的结果.针灸可通过提高线粒体电子密度、增加线粒体数量、减少线粒体空泡化从而调节线粒体形态;针灸可通过提高线粒体呼吸链复合物Ⅰ、Ⅱ、Ⅲ和Ⅳ等活性,增加ATP含量;针灸可通过调控线粒体视神经萎缩蛋白1、线粒体融合蛋白1、线粒体动力样蛋白1 表达量,恢复线粒体动力学平衡;针灸可通过降低肿瘤坏死因子-α、干扰素-γ、血清白介素-6 等炎性因子含量,减轻炎症对线粒体损伤;针灸可通过升高超氧化物歧化酶、谷胱甘肽过氧化物酶,降低丙二醛含量,抑制氧化应激反应,提高线粒体代谢;针灸可通过提高单磷酸腺苷激活的蛋白激酶/过氧化物酶体增殖物活化受体γ共激活因子α表达,促进线粒体生物合成发挥治疗作用.本文对以上机制进行总结分析,以期为研究针灸治疗CFS机制方面提供新的方向.

外文摘要：Acupuncture has a positive effect on chronic fatigue syndrome(CFS),and its mechanism studies mainly focus on the control of inflammatory response,regulation of immune response,anti-peroxide stress mechanism,regulation of neuroendocrine function,etc.,but there is insufficient regulation of mitochondrial metabolism.Based on this,this paper reviewed the relevant literature on the treatment of CFS by acupuncture based on the mechanism of mitochondrial metabolism,and the results showed that the regulation of mitochondrial function by acupuncture to treat CFS was the result of multi-level and multi-target interaction.Acupuncture could improve mitochondrial morphology by increasing mito-chondrial electron density,increasing mitochondrial number and reducing mitochondrial vacuolation.Acupuncture could increase the activity of mitochondrial respiratory chain complexⅠ,Ⅱ,Ⅲ and Ⅳ and increase the content of ATP.Acupuncture restored the mitochondrial dynamic balance by regulating the expression levels of fusion protein OPA1,MFN1 and fission protein DRP1.Acupuncture could reduce the content of TNF-α,INF-γ,serum IL-6 and other inflammatory factors to reduce the damage of inflammation on mitochondria.Acupuncture could increase the levels of SOD and GSH-Px,decreased the level of MDA,inhibit oxidative stress and improve mitochondrial metabolism.Acupuncture played a therapeutic role by increasing the expression of AMPK/PGC-1α and promoting mitochondrial biosynthesis.In this paper,the above mechanisms were summarized and analyzed in order to provide a new direction for studying the mechanism of acupuncture treatment of CFS.

外文关键词：

acupuncturechronic fatigue syndromemitochondrial metabolismmitochondrial respiratory chainmitochondrial dynamicsmechanism researchreview

作者：

张琳、马巧琳、于冬冬、崔家禾、宋甲奇、游晓阳、胡斌

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作者单位：

450046 郑州,河南中医药大学针灸推拿学院

河南中医药大学第三附属医院针灸科

河南中医药大学第三附属医院肿瘤科二病区

河南中医药大学第三附属医院康复科二病区

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关键词：

针灸慢性疲劳综合征线粒体代谢线粒体呼吸链线粒体动力学机制研究综述

基金：

河南省中医药科学研究专项重点课题中医药传承与创新人才工程(仲景工程)中医药拔尖人才项目

项目编号：

2019ZY1025豫卫中医函[2021]15号

出版年：

2024

DOI：

10.3969/j.issn.1674-1749.2024.06.041

环球中医药

中华国际医学交流基金会

环球中医药

CSTPCD

影响因子：1.553

ISSN：1674-1749

年,卷(期)：2024.17(6)