首页|当归的有效成分及药理作用研究进展

当归的有效成分及药理作用研究进展

扫码查看
当归是中医常用的一种药食同源中药材,含有多种化学成分,具有多种药理功效.由于当归所含的当归多糖、有机酸和挥发油类是影响其生物活性、药理作用和药材质量的主要成分,故分析当归有效成分的提取技术和制备工艺对于当归生物活性成分筛选和功能探索至关重要.关注不同成分的分离提取方法,改进药物作用模式,挖掘更加高效、稳定、绿色环保的提取工艺是现今当归提取、质量控制及药物开发利用的有效途径.此外,现代药理研究表明,当归多糖、阿魏酸和当归挥发油是当归发挥造血、免疫调节、抗肿瘤、肝保护、神经保护等作用的主要标志化合物.这些化合物的药理作用机制研究已经得到充分证实,显示出当归在干预疾病方面具有独特的治疗优势,并在功能食品开发、药物创新研发方面具有显著的潜力.因此,本文主要关注当归的新型提取工艺技术、主要活性成分、药理作用及相关作用机制和应用等方面的研究进展,旨在为将来当归药物创新、活性成分和靶点开发提供科学有效的理论基础和思路.
Research progress on active components and pharmacological action of Angelica sinensis
Angelica sinensis is a medicinal plant commonly used in traditional Chinese medicine,which contains a variety of chemical constituents and pharmacological effects. Angelica polysaccharides,organic acids,and volatile oils are the main components that influence the bioactivity,pharmacological effects,and quality of angelica sinensis. It is important to analyze the extraction technology and preparation process of Angelica sinensis for screening its bioactive components and exploring its functions,focusing on the separation and extraction of different components,improving the mode of action of the drug and exploring a more efficient,stable and environmentally friendly extraction process,which is an effective way for extraction,quality control and utilization of Angelica sinensis nowadays. In addition,modern pharmacological studies have shown that Angelica polysaccharides,ferulic acid,and volatile oil of angelica are the main marker compounds for the beneficial effects of angelica in hematopoiesis,immunomodulation,antitumor,hepatoprotection,and neuroprotection,etc. The studies on the pharmacological mechanism of these compounds have been sufficiently confirmed,and they show a unique therapeutic advantage in intervening in the diseases,and they have a significant potential for the development of functional foods and research and development of drug innovation. Therefore,this paper focused on the novel extraction process technology,major active ingredients,pharmacological effects and related mechanisms of action and applications of Angelica sinensis,aiming to provide a scientific and effective theoretical basis and ideas for the future development of angelica sinensis drug innovation,active ingredients and targets.

Angelica sinensischemical compositionextraction methodpharmacological effectsbiological activitymechanism of actionfunctional applications

周美丽、韩妮萍

展开 >

650500 昆明,云南中医药大学基础医学院

云南省中西医结合慢病防治重点实验室

当归 化学成分 提取方法 药理作用 生物活性 作用机制 功能应用

国家自然科学基金

82060815

2024

环球中医药
中华国际医学交流基金会

环球中医药

CSTPCD
影响因子:1.553
ISSN:1674-1749
年,卷(期):2024.17(7)
  • 6